内皮祖细胞与粥样斑块稳定性研究进展

Advances in Research on Endothelial Progenitor Cells' Function on Stability of Atheromatous Plaque

动脉粥样硬化是最常见的和最具危害性的疾病,给人民健康带来很大威胁,而粥样斑块内滋养血管新生,加重斑块负担,使斑块由稳定状态转变为不稳定状态,增加患者发生急性心肌梗死、脑卒中等的风险。由骨髓衍生的内皮祖细胞,促进再内皮化恢复血管受损内皮的完整性,同时增加缺血缺氧部位的血管新生,对粥样斑块形成及发展均产生影响。因此现将重点探讨内皮祖细胞与滋养血管的关系及对动脉粥样硬化斑块稳定性的影响。

Atherosclerosis is one of the most common and harmful diseases in modern life. Vasa vasorum in atherosclerosis can turn stable plaque into unstable plaque,thereby increasing the risk of acute myocardial infarction,stroke,etc. However,endothelial progenitor cells may promote restoration of the injured endothelium and increase angiogenesis of hypoxic-ischemic areas during atherosclerosis. This review examines the relationship between endothelial progenitor cells and vasa vasorum,and the effect of endothelial progenitor cells on the progression of atherosclerotic plaque.