摘要
肌钙蛋白是心肌损伤最敏感及特异的标志物,在心肌细胞崩解坏死时即可升高。肌钙蛋白升高作为诊断急性冠状动脉综合征的金标准。但一些研究发现,很多临床疾病可出现肌钙蛋白的升高,包括心力衰竭、心肌炎/心包炎、心肌病、心律失常、射频消融后、主动脉夹层、呼吸系统疾病(肺栓塞、慢性阻塞性肺疾病加重期)、脑卒中、脓毒血症及糖尿病、上消化道出血等,目前还无确切的解释来阐述肌钙蛋白在这些疾病中升高的机制。当其他的检查结果不典型时,往往很难将急性冠状动脉综合征鉴别出来。这篇综述旨在回顾众多研究的数据,从而有助于急性冠状动脉综合征与其他非冠状动脉疾病的鉴别。
Troponin is the most sensitive and specific biomarker of cardiac injury. Several studies report that many cardiac diseases and non-cardiac diseases show elevated levels of troponin including heart failure,myocarditis /pericarditis,cardiomyopathy,aortic dissection,respiratory disease（ pulmonary embolism,COPD excerbation）,stroke,sepsis,diabetes mellitus,upper gastrointestinal bleeding,and more. At present,it is not understood what causes the levels of troponin to increase. The current strategy involves treating the underlying causes. This review examines the diseases that can result in troponin elevation.
出处
《心血管病学进展》
CAS
2014年第4期506-510,共5页
Advances in Cardiovascular Diseases
