大株红景天胶囊对不稳定性心绞痛患者血栓形成的影响

Influence of Big Plant Rhodiola Capsule Treat on Unstable Angina Patients

目的:探讨大株红景天胶囊治疗不稳定性心绞痛(UA)的疗效及对血液流变学及血小板活化功能方面的影响。方法:将92例UA患者随机按住院前后分为对照组和观察组各46例。对照组服用拜阿司匹林肠溶片,100 mg/次;琥珀酸美托洛尔缓释片,47.5 mg/次,1次/d,晨服。马来酸依那普利片,10 mg/次,2次/d。阿托伐他汀钙片,20 mg/次,1次/d,晚餐后服用。心绞痛发作难以自行缓解者,硝酸甘油片,1片/次,必要时舌下含服。观察组在对照组治疗的基础上加服大株红景天胶囊,4粒/次,3次/d。两组疗程均为8周。检测治疗前后心电图;记录观察期内心绞痛发作次数和硝酸甘油片用量;进行治疗前后西雅图心绞痛量表(SAQ)评分;检测治疗前后血液流变学指标;检测治疗前后血小板α-膜颗粒蛋白(GMP-140)、血栓素B2(TXB2)、定血管性假血友病因子(vWF)、纤溶酶原激活物抑制剂1(PAI-1)水平。结果:治疗后观察组GMP-140,TXB2,vWF及PAI-1水平低于对照组(P<0.01);治疗后观察组全血黏度(高切、低切)、全血还原黏度、血浆黏度、纤维蛋白原和血小板聚集率的改善优于对照组(P<0.01);治疗后观察组每周心绞痛发作次数及硝酸甘油片用量均少于对照组(P<0.01);治疗后观察组SAQ评分高于对照组(P<0.01);观察组心电图疗效总有效为93.48%,对照组为78.26%,观察组优于对照组(P<0.05)。结论:在西医常规治疗的基础上,大株红景天胶囊能减少UA患者心绞痛发作次数,提高SAQ评分,其疗效可能与改善患者血液流变性,改善血小板功能,抑制血栓形成有关。

Objective：To discuss curative effect of big plant rhodiola capsule to treat unstable angina （UA） and the influence of hemorheology and hematoblastic activation function.Method：Ninety-two patients were randomly divided into control group （46 cases） and observation group （46 cases） by the sequence of being in hospital.Patients in control group received aspirin enteric-coated tablets,100 mg/time,metoprolol succinate sustained-release tablet,47.5 mg/time,1 does/day,taken in the morning,enalapril maleate tablets,10 mg/ time,2 does/day,atorvastatin calcium tablets,20 mg/time,1 does/day,taken after dinner.For patients who were hard to relieve himself with angina,took nitroglycerin tablets,1 piece/time,keeping under tongue when necessary.Patients in observation group took big plant rhodiola capsule based on the treatment of control payients,4 pieces/time,3 does/day.Both treatment courses continued 8 weeks.Test electrocardiogram before and after treatment.Record angina pectoris＇ attack frequency and dosage of nitroglycerin tablets during observation time.Give a mark of seattle angina questionnaire （SAQ） before and after treatment.Detect hemodynamic indexes and the level of platelet-α membrane protein particles （GMP-140）,thromboxane B2 （TXB2）,false yon willebrand factor （vWF）,plasminogen activator inhibitor 1 （PAI-1） before and after treatment.Result：After treatment,levels of GMP-140,TXB2,vWF and PAI-1 in observation group were lower than those in control group （P ＜0.01）.Amelioration of whole blood viscosity （low shear and high shear）,blood reduced viscosity,plasma viscosity,fibrinogen and platelet aggregation rate in observation group were superior to those in control group （P ＜0.01）.Attack times of angina every week and dosage of nitroglycerin tablets in observation group were both less than those in control group （P ＜0.01）.SAQ scores in observation group was higher than in control group （P ＜ 0.01）.And the total effective rate of electrocardiogram curative efficacy in observation group was 93.48％ superior to 78.26％ in control group （P ＜0.05）.Conclusion：Based on the conventional western medicine treatment,Dazhu Hongjingtian capsules can reduce attack times of angina and improve SAQ scores,the curative efficacy may be related to ameliorate patients＇hemorheology and functions of platelet,and inhibit thrombogenesis.