颈动脉粥样硬化与冠状动脉、肾动脉狭窄的相关性研究

The correlation between carotid atherosclerosis and coronary artery,renal atherosclerosis

目的探讨颈动脉与冠脉、肾动脉粥样硬化的相关性。方法 129例患者冠状动脉造影后即刻行肾动脉造影及颈动脉超声,记录临床资料和造影结果,进行颈动脉硬化评分。结果 129例患者中,冠心病者81例,占62.8%;肾动脉狭窄患者68例,占52.7%。颈动脉硬化越重,冠脉病变支数越多,肾动脉狭窄发病率越高,狭窄程度越重(P<0.05);冠脉狭窄程度与年龄、高血压、高血脂、GLU、颈动脉硬化评分及肾动脉狭窄正相关(P<0.05),与HDL负相关(P<0.05);肾动脉狭窄程度与年龄、高血压、高血脂、吸烟、CR、颈动脉硬化评分及冠脉狭窄程度正相关(P<0.05),与HDL负相关(P<0.05)。结论颈动脉硬化指数与冠脉病变程度相关,颈动脉与冠脉、肾动脉粥样硬化之间存在共同的危险因素。颈动脉硬化评分可作为冠状动脉粥样硬化的预测因子。

Objective To investigate the correlation between carotid atherosclerosis and coronary artery, renal atherosclerosis. Methods One hundred and twenty - nine patients were examined by coronary arteriongraphy, then examined immediately by renal arteriography and carotid artery ultrasound, and the clinical data and arteriography results were recorded to carry out carotid atherosclerosis scoring. Results Among 129 patients, there were 81 cases of coronary heart disease （62.8%） ,68 cases of renal artery stenosis （52.7%）. The more severe the carotid atherosclerosis, the more blood vessel number of coronary artery pathological change ; the higher the incidence of artery stenosis, the more severe the stenosis degree. The stenosis degree of coronary artery was positively correlated to patient＇ s age, history of hypertension, hyperlipemia, blood sugar, carotid atherosclerosis scoring, however, which was negatively correlated to high density lipoprotein （HDL）. The stenosis degree of renal artery was positively correlated to patient＇ s age, history of hypertension, hyperlipemia, smoking history, creatinine,carotid atherosclerosis scoring and stenosis degree of coronary artery however, which was negatively correlated to HDL. Conclusion The carotid atherosclerosis index is related with pathological change degree of coronary artery, and carotid atherosclerosis and coronary artery, renal atherosclerosis have congenerous risk factors. So carotid atherosclerosis scoring can be regarded as predictive factor for coronary atherosclerosis.