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新诊断2型糖尿病合并非酒精性脂肪肝与代谢综合征关系研究 被引量:3

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摘要 目的探讨初发2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)与代谢综合征的相关性。方法T2DM住院患者148例与健康对照者60例,采用彩色多普勒超声检查诊断NAFLD,应用Logistic回归分析初发2型糖尿病合并非酒精性脂肪肝与代谢综合征的相关性。结果 3组间腰围、WHR、FINS、ALT、AST、TG、HDL-c、HOMA-IR、BMI、CHO、LDL-c、BUN、收缩压(SBP)比较差异有统计学意义(P<0.05或<0.01)。FPG、HbA1c、尿Alb/Cr、Cr、舒张压(DBP)比较,差异无统计学意义(P>0.05)。多元线性逐步回归分析显示WHR、SBP、HOMA-IR、BMI、腰围、TG与初发T2DM合并NAFLD独立相关(P<0.05或<0.01)。结论初发2型糖尿病合并非酒精性脂肪肝具有明显肥胖症和代谢紊乱,胰岛素抵抗可能是2型糖尿病合并非酒精性脂肪肝的重要危险因素。
出处 《河北医药》 CAS 2014年第17期2633-2634,共2页 Hebei Medical Journal
基金 张家口市科学技术研究与发展计划项目(编号:11110024D)
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  • 1Luyckx FH, Lefebvre PJ, Scheen AJ. Nonalcoholic stestohepatitis: association with obesity and insulin resistance, and influence of weightloss[J]. Diabetes Metab,2000,26(2) :98 - 106.
  • 2Cortez PH, Camilo ME, Baptista A, et al. Nonalcoholic fatty liver: another feature of the metabolic syndrome [ J ]. Clin Nutr, 1999,1 ( 6 ) : 353 -358.
  • 3Collantes R, Ong JP, Younossi ZM. Nonalcoholic fatty liver disease and the epidemic of obesity[ J]. Cleve Clin J Med,2004,71:657 -664.
  • 4Elbein SC,Wegner K,Kahn SE.Reduced β-cell compensation to the insulia resistance associated.With obesity in members of Caucasian familial type α diabetic kindreds.Diabetes Care,2000,23:221-227.
  • 5Katz A,Nambi SS,Mather K,et al.Quantitative insulin sensitivity check index:a simple,accurate method for assessing insulin sensitivity in humans.Clin Endocrinol Metab,2000,85:2402-2410.
  • 6Reder ME,Schwartz RS,Prigeon RL,et al.Reduced pancreatic B cell compensation to the insulin resistance of aging:impact on proinsulin and insulin levels.J Clin Endocrinol Metab,2000,85:2275-2280.
  • 7Kahn BB.Type ll diabetes:when insulin secretion fails to compensate for insulin resistance.Cell,1998,92:593-596.
  • 8Del Prato S,Tiengo A.The importance of first-phase insulin secretion:implications for the therapy of type α diabetes mellitus.Diabetes Metab Res Rev,2001,17:164-174.
  • 9Looker HC,Knowler WC,Hanson RL.Changes in BMI and Weight before and after the development of type α diabetes.Diabetes Care,2001,24:1917-1923.
  • 10De Cristofaro R,Rocca B,Vitacolonna E.et al.Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus.J Thromb Haemost,2003,1:250-256.

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