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布托啡诺和右美托咪定对拔管期血流动力学的影响 被引量:10

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摘要 目的观察布托啡诺复合右美托咪定对拔管期血流动力学的影响。方法拟行腹腔镜妇科手术患者90例,随机分为A、B、C 3组,每组30例,采用气管插管全身麻醉。手术结束前15 min内A组静脉输注布托啡诺1 mg和右美托咪定0.5μg/kg,B组注射右美托咪定0.5μg/kg,C组注射等剂量生理盐水。观察麻醉诱导前(T1),拔管后1 min(T2)、5 min(T3)的心率(HR)和平均动脉压(MAP),拔管时的呛咳反应,术后1、2、4、8 h的视觉模拟评分(VAS),术后24 h内恶心、呕吐和寒战的发生率。结果 T2、T3时点HR和MAP比较,B、C组高于同组T1时点,A组低于B、C组同时点,B组低于C组同时点(P<0.05)。术后1、2、4 h VAS比较,A组低于B、C组,B组低于C组(P<0.05)。A、B组轻度呛咳反应多于C组,重度呛咳反应少于C组(P<0.05),术后寒战发生率A、B组少于C组(P<0.05)。结论布托啡诺复合右美托咪定可有效抑制拔管期血流动力学波动,且能抑制寒战。
出处 《广东医学》 CAS CSCD 北大核心 2014年第15期2434-2436,共3页 Guangdong Medical Journal
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参考文献11

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