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靶向硫氧还蛋白系统抗肿瘤药物的研究进展 被引量：1

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摘要 硫氧还蛋白(Trx)/硫氧还蛋白还原酶(TrxR)在许多人原发性肿瘤中和肿瘤病人的血样中是高表达的。其在促进肿瘤细胞增殖、抑制细胞凋亡、促进肿瘤耐药发生等事件中起到关键的推动作用,通过化疗药物抑制TrxR的活性已成为有效的癌症靶向治疗策略。国内外都开展了硫氧还蛋白系统抑制剂的探索工作,目前国际上进入临床研究的硫氧还蛋白系统的靶向药物只有三种,本文针对临床在研的这三种药物进行总结,以期开发出新型更高效的抗肿瘤新药。
作者 李冬冬 陶遵威
机构地区 天津市医药科学研究所
出处 《天津药学》 2014年第4期64-67,共4页 Tianjin Pharmacy
关键词 硫氧还蛋白系统 细胞凋亡 肿瘤治疗
分类号 R979.1 [医药卫生—药品]
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参考文献27

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天津药学
2014年 第4期

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