4Ahren B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab,2004,89: 2078 -2084.
5Balas B, Baig MR, Watson C, et al. The dipeptidyl peptidasc IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients. J Clin Endocrinol Metab,2007 ,92 :1249-1255.
6Marl A, Sallas WM, He YL, et al. Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes. J Clin Endocrinol Metab,2005,90: 4888- 4894.
7Matikainen N, Manttari S, Schweizer A, et al. Vildagliptin therapy reduces postprandial intestinal triglyeeride-rieh lipoprotein particles in patients with type 2 diabetes. Diabetologia,2006,49:2049-2057.
8Vella A, Bock G, Giesler PD, et al. Effects of dipeptidyl peptidase 4 inhibition on gastrointestinal function, meal appearance and glucose metabolism in type 2 diabetes. Diabetes,2007,56 : 1475-1480.
9Dejager S, Razac S, Foley JE, et al. Vildagliptin in drug-naive patients with type 2 diabetes : a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res ,2007 ,39 :218-223.
10Pi-Sunyer FX, Schweizer A Mills D, et al. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract ,2007 ,76 :132-138.
1UK Prospective Diabetes Study (UKPDS) Group. Intensive blood -glu- cose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes ( UK- PDS 33) [J]. Lancet,1998, 352(9131) :837 - 853.
2Bouhon D,Tang A, Patel C, et al. Pharmacokinetics of the dipeptidyl peptidase -4 inhibitor saxagliptin in subjects with renal impairment[ J]. Endo Abstr,2009 ,20 :357.
3Barnett A H, Charbonnel B, Donovan M, et al. Effect of saxagliptin as add - on therapy in patients with poorly controlled type 2 diabetes on in- sulin alone or insulin combined with metformin[ J]. Curr Med Res Opin, 2012,28(4) :513 -523.
