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2013年中日友好医院临床分离细菌耐药性分析 被引量:5

Bacterial resistance surveillance analysis of most common clinical isolates from China-Japan Friendship Hospital in 2013
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摘要 目的:分析2013年医院临床分离病原菌分布和耐药性,为临床治疗经验性用药提供参考依据。方法:采用VITEK-2进行细菌鉴定和药物敏感试验测定,使用Whonet5.6软件进行数据统计分析。结果:2013年医院共分离出病原菌3977株,排名依次为大肠埃希菌(14.3%)、鲍曼不动杆菌(9.2%)、肺炎克雷伯菌(8.9%)、铜绿假单胞菌(8.8%)、凝固酶阴性葡萄球菌(7.6%)、金黄色葡萄球菌(7.3%)、粪肠球菌(4.6%)、屎肠球菌(3.5%),其中肠杆菌科菌中大肠埃希菌和肺炎克雷伯菌的耐碳青霉烯酶菌株检出率分别为0.9%(5/567)、3.1%(11/354);非发酵菌中鲍曼不动杆菌和铜绿假单胞菌对亚胺培南/美洛培南的耐药率分别57.2%/72.4%和21.5%/19.9%;葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率分别为50.0%(146/292)和78.7%(237/301),未发现对万古霉素、利奈唑胺、替加环素的耐药株;肠球菌属中耐万古霉素粪肠球菌和屎肠球菌检出率分别为0.6%(1/183)和20.7%(29/140),未发现替加环素的耐药株。结论:细菌耐药呈增长趋势,需加强耐药性监测,并有效控制抗菌药物的使用。 Objective:To investigate the clinical pathogen distribution and resistance profile to antimicrobial a gents from China-Japan Friendship Hospital in 2013.Methods:The identification and antimicrobial susceptibility test of the isolates were determined by VITEK-2.All the data were analyzed by Whonet 5.6 software.Resuits:3977 strains were isolated in 2013.The main pathogenic species were as follows:Escherichia coli(ECO) (14.3%) ,Acinetobacter baumannii (ABA) (9.2%) ,Klebsiella pneumoniae ss.Pneumoniae (KPN) (8.9%) ,Pseudomonas aeruginosa (PAE) (8.8%), coagulase-negative Staphylococcus (CNS) (7.6%), Staphylococcus aureus ss. Aureus (SAU) (7.3%), Enterococcus faecalis (EFA) (4.6%), Enterococcus faecium (EFM) (3.5%).The detection rate of carbapenemase-resistant Enterobacteriaceae (CRE)was 0.9% (5/567)in ECO and 3.1%(11/354)in KPN.The resistant rate of Imipenem and Meropenem in non-fermentative bacteria were 57.2%/72.4% in ABA and 21.5%/19.9% in PAE.The detection rate of MRSA and MRCNS were 50.0%(146/292)and 78.7%(237/301), respectively.The detection rate of Vancomycin-resistant Enterocoecus(VRE)was 0.6%(1/183)in EFA and 20.7% (29/140) in EFM.Conclusion:The resistance of bacteria is still increasing,surveillance of antimicrobial agents is very important.
出处 《中日友好医院学报》 2014年第4期198-203,共6页 Journal of China-Japan Friendship Hospital
基金 传染病预防控制国家重点实验室自主研究开放课题(2012SKLID313) 国家科技支撑计划课题(2012BAH24F05)
关键词 细菌 抗菌药物 耐药监测 bacteria antimicrobial agents resistance surveillance
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参考文献8

  • 1CLSI.Performance standards for antimicrobial susceptibility testing;twentieth informational supplement [S].MIO0-$23, 2013.
  • 2汪复,朱德妹,胡付品,蒋晓飞,胡志东,李全,孙自镛,陈中举,徐英春,张小江,王传清,王爱敏,倪语星,孙景勇,褚云卓,俞云松,林洁,徐元宏,沈继录,苏丹虹,卓超,魏莲花,吴玲,张朝霞,季萍,张泓,孔菁,胡云建,艾效曼,单斌,杜艳.2012年中国CHINET细菌耐药性监测[J].中国感染与化疗杂志,2013,13(5):321-330. 被引量:465
  • 3吴森泉,邱晨.碳青霉烯类耐药肠杆菌科细菌研究现状[J].广东医学,2013,34(17):2718-2721. 被引量:7
  • 4Van DuinDV,Kaye RS,Neuner EA,et al.Carbapenem resis- tant Entero- bacteriaceae:a review of treatment and out- comes[J].Diagn Microbiol Infect Dis,2013,75(2):l15-120.
  • 5Coyne S,Guigon G,Courvalin P,et al.Screening and quan- tification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray[J].Antimicrob A- gents Chemother,2010,54(1) :333-340.
  • 6Lee K,Yong D,Jeong SH,et al.Multidrug-resistant Acineto- bacter spp:increasingly problematic nosocomial pathogens[J]. Yonsei Med J ,2011,52(6) : 879-891.
  • 7沈丹,薛婧,张蕊,王伏星,王楠.某三甲医院鲍曼不动杆菌耐药性分析[J].武警医学,2013,24(10):869-871. 被引量:6
  • 8Cohen SH,Gerding DN,Johnson S,et al.Clinical practice guidelines for Clostridium difficile infection in adults:2010 update by the society for heahhcare epidemiology of Amer- ica (SHEA)and the infectious diseases society of America (IDSA)[J].Infect Control Hosp Epidemiol,2010,31 (5) :431- 455.

二级参考文献62

  • 1朱旭慧,孙自镛,简翠,李丽,张蓓,申正义.不动杆菌属的耐药性分析[J].中国抗感染化疗杂志,2005,5(6):342-345. 被引量:37
  • 2CLSI Performance standards for antimicrobial susceptibility testing[S]. Twenty second Informational supplement M100- S22 2012,32(3).
  • 3European Committee on Antimicrobial susceptibility testing, Breakpoint tables for interpretation of MICs and zone diame- ters[S]. Version 2, 2012, valid from 2012-01-01.
  • 4Bush K. Alarming β-lactamase mediated resistance in multi- drug-resistant Enterobacteraceae[J]. Curr Opinion Microbi- oh 2010, 13(5): 558-564.
  • 5Nordmann P, Dortet L, Poirel L. Carbepenem resistance in Enterobacteriaceae: here is the storm! [J]. Trends Mol Med, 2012, 18(6): 263-271.
  • 6Hu FP, Chen SD, Xu XG, et al. Emergence of carbapenem resistant clinical Enterobacteriaceae isolates from a teaching hospital in Shanghai, China[J]. J Med Microbiol, 2012,61 (Ptl) : 132-136.
  • 7Yang Q, Wang H, Sun H, et al. Phenotypic and genotypic characterization of Enterobacteriaceae with decreased suseep tibility to carbapenems: results from large hospital-based sur veillance studies in China[J]. Antimicrob Agents Chemoth er, 2010, 54(1):573-577.
  • 8Chen SD, Hu FP, Xu XG, et al. High prevalence of KPC-2 carbapenemase coupled with CTX-M-type extended-spectrum 13-1actamase in carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China[J]. Antimierob Agents Che- mother, 2011, 55(5) :2493-2444.
  • 9Hawser SP, Bouchillon SK, Lascols C, et al. Susceptibility of Klebsiella pneumoniae isolates from intra-abdominal infec- tions and molecular characterization of ertapenem-resistant i- solates[J]. Antimicrob Agents Chemother, 2011, 55 (8) : 3917-3921.
  • 10Lascols C, Peirano G, Hackel M, et al. Surveillance and mo- lecular epidemiology of Klebsiella pneumoniae isolates that produce Carbapenemase:first report of OXA-48-1ike enzymes in north America[J]. Antimicrob Agents Chemother, 2013, 57(1):130-136.

共引文献475

同被引文献69

  • 1肖永红.合理使用抗菌药物,应对细菌耐药挑战[J].中国医学前沿杂志(电子版),2013,5(1):4-8. 被引量:19
  • 2王传清,王爱敏,张泓,李万华,孙自镛,简翠,徐英春,孙宏莉,俞云松,杨青,胡云建,艾效曼,倪语星,孙景勇,汪复,胡付品,朱德妹,张朝霞,季萍,徐元宏,沈继录,卓超,苏丹虹,魏莲花,吴玲,单斌,杜艳,黄文祥,贾蓓.2009年中国CHINET链球菌属细菌耐药性监测[J].中国感染与化疗杂志,2010,10(6):426-429. 被引量:30
  • 3Mclntosh K. Communty-aequired pneumonia in children[ J]. N Engl J Med ,2002 ( 346 ) :429-437.
  • 4中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南(试行)(上)[J].中华儿科杂志,2007(45):83-90.
  • 5Harris M, Clark J, Coote N, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in children: uodate 2011 [ J ]. Thorax,2011,66 ( Suppl ) 2:1-23.
  • 6Ruuskanen O, Lahti E, Jennings LC, et al. Viral pneumonia [ J ]. Lancet,2011 (377) :1264-1275.
  • 7Garcia Garcia ML, Calvo C, Pozo F, et al. Spectrum of respiratory vi- ruses in children with community-acquired pneumonia [ J ]. Pediatr Infect Dis J,2012(31) :808-813.
  • 8John S,Bradley, carrie L, Byington, et al. The infanagement of com- munity-acquired pneumonia in infants and children older than 3 months of age : Clinical practice guidelines by the Pediatric infectious Diseases society and the Infectious Diseases Society of America[ J ]. Clin infect Dis,2011,53 (7) : e25-76.
  • 9李杨方,吴茜,倪林仙,赵明波,高丽,陈祝,樊茂,苏敏.新生儿感染性肺炎病原学检测及临床研究[J].中国新生儿科杂志,2008,23(3):137-140. 被引量:26
  • 10沈晖,刘兴,谭鑫,胡金伟.206例儿童细菌性肺炎病原菌分布及耐药性分析[J].实用预防医学,2010,17(2):358-360. 被引量:19

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