GSTM1基因、吸烟及饮酒与亚洲人群口腔癌易感性的Meta分析

GSTM1 polymorphism,smoking,alcohol drinking and oral cancer susceptibility in Asians: A meta-analysis

目的：采用循证医学Meta分析方法评价谷胱甘肽-S-转移酶M1（GSTM1）基因多态性、吸烟及饮酒与亚洲人群口腔癌易感性的关联。方法：计算机检索PubMed、CBM、万方、维普、CNKI等中英文数据库，检索范围从建库至2013-07-30全面收集相关文献数据计算优势比（OR）及95％置信区间（95％CI）以评价关联性。结果：纳入27项病例对照研究，结果：GSTM1缺失基因型与亚洲人群口腔癌发病风险显著相关（OR＝1．31，95％CI：1．18～1．45，P＜0．001），在南亚人群中尤为显著（OR＝1．35，95％CI：1．20～1．52，P＜0．001）；吸烟和饮酒与口腔癌易感性之间的关联在东亚人群中显著（吸烟：OR＝1．70，95％CI：1．36～2．13，P＜0．001；饮酒：OR＝1．54，95％CI：1．24～1．90，P＜0．001），在南亚人群中不显著。结论：GSTM1缺失基因型与亚洲人群口腔癌易感性显著关联，吸烟和饮酒与口腔癌易感性在东亚人群中显著关联。

Objective：To evaluate the association of glutathione S-transferase M1 （GSTM1 ） polymorphism,smoking and alcohol drinking with oral cancer susceptibility in Asians by meta-analysis.Methods：A literature search of PubMed,Chinese BioMedical, Wanfang,VIP and CNKI databases from inception to July 30th,2013 was conducted.Crude odd ration （OR）with 95% confidence intervals （95%CI）was calculated.Results：27 case-control studies were assessed,and the results showed that the association between GSTM1 null genotype and oral cancer susceptibility was significant in Asians （OR=1.31,95%CI：1.18-1.45,P〈0.001）, especially in South Asians （OR=1.35,95%CI：1.20 -1.52,P〈0.001）.Significant associations between oral cancer risk and smoking and alcohol drinking were found in East Asians （Smoking：OR=1.70,95%CI：1.36 -2.13,P〈0.001;Alcohol drinking：OR=1.54,95%CI：1.24 -1.90,P〈0.001）.Conclusion：GSTM1 null genotype may be associated with increased oral cancer risk in Asians.Smoking and alcohol drinking confer significant susceptibility to oral cancer in East Asians.