高气压下应用改良呼吸装置吸入混合氧治疗脑梗死的临床效果

Clinical effect of hyperbaric oxygen with the addition of carbon dioxide inhaled through modified breathing equipment on patients with cerebral infarction

目的探讨应用改良呼吸装置吸入高压混合氧治疗脑梗死的疗效,评估高压氧舱内改良呼吸模式的应用价值。方法选择符合要求的脑梗死患者80例,随机分为高压混合氧组和高压氧组,每组40例。在常规药物治疗基础上,高压混合氧组应用改良呼吸装置吸入高压混合氧(98%O2+2%CO2)治疗,高压氧组吸入高压纯氧治疗。两组患者治疗前后均采用美国国立卫生研究院卒中量表(NIHSS)评价神经功能缺损程度;采用Barthel指数评分评价日常生活活动能力(ADL)。结果治疗前两组患者NIHSS评分和ADL评分的差异均无统计学意义(P>0.05)。与治疗前相比,治疗后两组患者NIHSS评分下降、ADL评分升高(P均<0.05)。治疗后高压混合氧组NIHSS评分较高压氧组降低,ADL评分升高(P均<0.05)。结论高压混合氧在发挥高压纯氧效应的同时,能够扩张血管,改善微循环,有效改善脑梗死患者的神经功能和日常生活能力,提高治疗效果。

Objective To evaluate the clinical effects of hyperbaric oxygen with the addition of carbon dioxide inhaled through modified breathing equipment on patients with cerebral infarction and to assess the application value of the equipment. Methods Eighty patients with cerebral infarction were divided into hyperbaric oxygen with the addition of carbon dioxide group（ HBO ＋ CO2group） and hyperbaric oxygen group（ HBO group）. 98% O2＋ 2% CO2 was adiministered in the HBO ＋ CO2 group,hyperbaric oxygen was adiministered in the HBO group. The score of National Institutes of Health Stroke Scale（ NIHSS） and activity of daily life（ ADL） were examined before and after the treatment.Results Prior to the treatment,NIHSS scores and ADL scores showed no statistically difference between the two groups（ all P〈0. 05）. After the treatment,the NIHSS score was significantly lower and ADL score was significantly higher than those before treatment in both groups（ all P〉0. 05）. After the treatment,NIHSS score of the HBO ＋ CO2 group decreased and ADL score increased more evidently than those of the HBO group（ all P〈0. 05）. Conclusion Hyperbaric oxygen with the addition of carbon dioxide can not only play the role of hyperbaric oxygen but also eliminate vasoconstriction simultaneously,and thus improve neurological functions and life quality of patients with cerebral infarction.