类风湿关节炎与TNFAIP3基因多态性关联研究的Meta分析

Meta-analysis of TNFAIP3 gene polymorphism with rheumatoid arthritis

目的探讨类风湿关节炎（RA）与肿瘤坏死因子诱导蛋白3（TNFAIP3）基因多态性的关联性。方法选择TNFAIP3基因6个位点（rs6920220、rs2230926、rs5029937、rs10499194、rs2327832、rs13207033）,检索已发表的RA与TNFAIP3基因多态性关联研究的文献进行Meta分析。结果 18篇文献共纳入27554例RA患者和39 664例正常对照。综合分析显示,TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联（P〈0.01,P=0.03,P=0.002）;TNFAIP3基因rs2327832和rs13207033位点基因多态性与RA无关联（P=0.27,P=0.05）。亚组分析显示,白种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=0.87（0.80-0.95）,P〈0.01];黄种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=1.28（1.13-1.46）,P〈0.01]。结论 Meta分析显示,TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联,rs10499194位点基因多态性与RA的关联有种族差异。

Objective To validate the association between rheumatoid arthritis（ RA） and tumor necrosis factor alpha induced protein 3（ TNFAIP3） gene polymorphism. Methods A total of 6 SNPs in TNFAIP3（ rs6920220,rs2230926,rs5029937,rs10499194,rs2327832,rs13207033） which had been extensively examined were selected. Published studies on RA and TNFAIP3 were retrieved and a Meta-analysis was conducted. Results Altogether 18 studies with 27 554 RA patients and 39,664 controls were included. The comprehensive analysis indicated that the gene polymorphism of rs6920220,rs2230926 and rs5029937 was associated with RA（ P〈0. 01,P = 0. 03,P = 0. 002）. The gene polymorphism of rs2327832 and rs13207033 was not associated with RA（ P = 0. 27,P = 0. 05）. The subgroup analysis revealed that the gene polymorphism of rs10499194 was associated with RA in white people [OR = 0. 87（ 0. 80-0. 95）,P〈0. 01]. The gene polymorphism of rs10499194 was associated with RA in yellow people[OR = 1. 28（ 1. 13-1. 46）,P〈0. 01]. Conclusion The Meta-analysis reveals that the gene polymorphism of rs6920220,rs2230926 and rs5029937 is associated with RA. The association between the gene polymorphism of rs10499194 and RA has racial differences.