糖尿病眼底动脉多普勒血流参数与糖化血红蛋白的相关研究

Evaluation of ocular fundus artery hemodynamics in diabetes and correlation study with glycosylated hemoglobin

目的通过分析糖尿病眼底动脉血流参数与糖化血红蛋白（GHb）之间的相关性，探讨糖尿病眼底动脉血流动力学评估的临床价值。方法糖尿病患者98例（196只眼），其中治疗前49例（98只眼），治疗后49例（98只眼）；正常对照组100例（200只眼）。检测各受检者GHb，应用彩色多普勒超声检测眼动脉（OA）、视网膜中央动脉（CRA）及睫状后动脉（PCA），比较糖尿病组与正常对照组眼底动脉血流参数，并分析眼底动脉血流参数与GHb的关系。结果糖尿病组眼底动脉的收缩期最大血流速度（PSV）和舒张末期血流速度（EDV）均下降，阻力指数（RI）增加，与正常对照组比较差异均有统计学意义（P＜0．05），糖尿病组治疗前后比较差异有统计学意义（P＜O．05）；GHb与眼底动脉PSV、EDV呈负相关（PSD：rPcA=-0．491，rcRA=-O．482，roAW=-0．602；EDV：rPcA=-0．427，’cRA=-O．489，roA=-0．509），与RI呈正相关（rpcn=0．464，rcnn=0．523，ron=O．611）。结论糖尿病眼底动脉血流动力学的评估可以为糖尿病视网膜灌注情况及功能改变提供有用的信息，对评价糖尿病视网膜的病程有重要的临床价值。

Objective To explore the value of ocular fundus artery hemodynamics in diabetes by the correlation study between ocular fundus artery and glycosylated hemoglobin （GHb）. Methods GHb was checked in 98 patients （196 eyes） in diabetes,including 49 cases （98 eyes） before treatment and 49 cases （98 eyes） after treatment,and normal group of 100 cases （200 eyes）.In all cases,color Doppler ultrasonography was used for monitorind ophthalmic artery（OA）, central retinal artery（CRA） and posterior ciliary artery （PCA）.Finally, the differences of the parameters vauels of the the OA,CRA,and PCA between diabetic and normal group were studied in order to find out the relationship with GHb. Results Of 98 patients in diabetes, peak systolic velocity and end diastolic velocity of fundus artery decreased, resistance index increased（RI）. There was significant difference between diabetic and normal group （P〈0.05）, and a significant difference was exited between diabetic group before and after treatment（ P 〈0.05）.GHb were negatively correlated with the velocity of fundus artery, and positively correlated with RI. Conclusions Evaluation of ocular fundus artery hemodynamics in diabetes can provide useful information for diabetic retinal perfusion and function change.For evaluation of diabetic retinal disease,it is of great value in clinical application.