脂联素基因多态性与非小细胞肺癌遗传易感性的关联

Association Study of Adiponectin Gene Polymorphisms with Genetic Predisposition of Non-small Cell Lung Cancer

目的探讨脂联素(adiponectin,Acrp30,ADIPO)基因启动子区域多态性与非小细胞肺癌(non-small cell lung cancer,NSCLC)的相关性.方法采用Taq Man探针基因分型方法对NSCLC患者(n=179)与健康体检人群(n=242)进行ADIPO基因启动子区域SNP-12140和SNP-11426两个位点进行基因分型,评估这2个SNPs与NSCLC发生的相关性,同时根据肺癌病理类型进行分层分析,评估这2个位点与NSCLC中与鳞癌和腺癌的相关性.结果病例组和对照组NSCLC基因SNP-12140位点基因型和等位基因频率差异有统计学意义(P<0.05),SNP-11426位点基因型和等位基因频率在病例组和对照组中无差异(P>0.05).在鳞癌和腺癌中SNP-12140和SNP-11426无差异(P>0.05).结论脂联素基因启动子区域SNP-11426与NSCLC的发生有关,其中A等位基因可能减少NSCLC的患病风险(OR=0.622,95%CI:0.398～0.971),但是该位点与肺癌的病理类型无相关性.

Objective This study aimed to investigate the association of adiponectin（ADIPO） gene polymorphisms with non-small cell lung cancer（NSCLC）. Methods 179 patients with NSCLC and 242 healthy controls in Chinese Han were enrolled in present study. Two single nucleotide polymorphisms（SNPs） of SNP-12140 and SNP-11426 in ADIPO gene were genotyped using TaqMan technique. The correlations between the two SNPs and NSCLC occurrence were evaluated. Results The genotypic and allelic frequencies of SNP-12140 showed significant difference between NSCLC and the control groups（P〉0.05）. However, the genotypic and allelic frequencies of these two SNPs showed no significant difference between the squamous carcinoma and the adenocarcinoma groups（P〈0.05）. Conclusion ADIPO SNP-12140 had a association with NSCLC, and SNP-12140 A allele was associated with decreased NSCLC risk（OR =0.622, 95% CI： 0.398 ～0.971）.However,SNP-12140 was not associated with the pathologic types of NSCLC.