2型糖尿病家系人群中糖尿病视网膜病变相关因素的分析

Risk Factors of Familial Type 2 Diabetes Mellitus with Diabetic Retinopathy

目的探讨2型糖尿病家系人群中DR的相关危险因素.方法采用调查问卷记录所有研究对象的相关临床资料并检测其生化指标;ELISA法测定真胰岛素、胰岛素原水平并进行统计学分析.结果 (1)先证者中,与不伴DR者相比,先证者伴DR者年龄(P<0.01)、糖尿病病程、FCP和PCP具有统计学意义(P<0.05).Logistic回归提示年龄和糖尿病病程是先证者DR发生的独立危险因子;(2)与先证者的糖尿病同胞不伴DR者比较,先证者的糖尿病同胞伴DR者A1C、Ca2+和PCP具有统计学意义(P<0.05).Logistic回归提示Ca2+是先证者同胞中DR发生的独立保护因子.结论先证者中,年龄和糖尿病病程是DR发生的危险因素,同胞中Ca2+是DR发生的保护因素.

Objective To analyze the risk factors of familial type 2 diabetes mellitus with diabetic retinopathy（DR）. Methods The questionnaire survey was conducted to collect the clinical data of all subjects, and the biochemical indexes were detected. ELISA was used to measure the levels of true insulin and proinsulin, and all data were analyzed statistically. Results（1） Compared to the T2 DM probands without DR,age（P 0.01）,duration of diabetes, FCP and PCP（P 0.05） in T2 DM probands with DR were statistically significant. The results of binary logistic regression analysis suggested that age and duration of diabetes were both risk factors for probands with DR.（2） Compared to the T2 DM siblings without DR,A1 C,Ca2＋ and PCP（P 0.05） in the T2 DM siblings with DR were statistically significant. The results of binary logistic regression analysis suggested that Ca^2＋ was the only independent protective factor for the T2 DM siblings with DR. Conclusion It suggested that age and duration of diabetes were both risk factors for the T2 DM probands with DR, and Ca2＋ was the only independent protective factor for the T2 DM siblings with DR in the population.