摘要
目的对照研究微创和常规开颅手术治疗双额叶挫伤患者的血清脑损伤特异性蛋白表达。方法将109例双额叶挫伤患者分为2组:微创组55例应用颅内压监护、单侧翼点入路经大脑镰开窗处理双侧病灶等微侵袭治疗技术,对照组54例选用常规双侧骨瓣开颅手术。采用酶联免疫吸附法(ELISA)测定患者血清神经元特异性烯醇化酶(NSE)、S-100β蛋白。结果微创组和对照组入院至手术时间分别为(5.23±1.05)h与(10.30±1.98)h,差异有显著性。微创组手术前后血清NSE、S-100β水平无明显差异,对照组术后1 d的NSE和S-100β表达较术前显著上调;微创组NSE、S-100β表达在术后1 d、3 d显著低于对照组。结论微创治疗双额叶挫伤在降低术后脑损伤特异性蛋白表达方面优于常规开颅术。
Objective The expression of serum specific protein for traumatic brain injury in bifrontal lobe contusion patients treated with minimally invasive surgery and routine bilateral eraniectomy are studied. Methods A total of 109 patients with bifrontal lobe contusion were divided into two groups： minimal invasive group and control group. The patients in minimal invasive group all received minimally invasive treatment, such as intraeranial pressure monitoring, removal of bifrontal hematoma via unilateral pterional approach and a falcine window. The patients in control group were performed with the routine bilateral craniectomy. Serum concentration of neuron specific enolase （NSE） and S-100β protein were determined by enzyme linked immunosorbent assay. Results The time from hospitalization to operation had a significant difference between minimally invasive group 5.23 h ± 1.05 h and control group 10.30 h ± 1.98 h. NSE and S-100β showed no obvious change postoperatively in minimally invasive group. Comparatively, NSE and S-100β level were increased in control group one day after operation. The expression of NSE and S-100β were lower in minimally invasive group than those in control group from 1 d and 3 d after operation. Conclusion Minimally invasive treatment significantly decreases the postoperative expression of serum specific protein for traumatic brain injury in patients with bifrontal lobe contusion. It indicates that the minimally invasive treatment has an advantage of reducing the brain injury of the operation compared with craniotomy.
出处
《中华神经外科疾病研究杂志》
CAS
2014年第4期329-331,共3页
Chinese Journal of Neurosurgical Disease Research
