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Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection 被引量:3

Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection
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摘要 Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as atrophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases. Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as atrophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.
出处 《Neuroscience Bulletin》 SCIE CAS CSCD 2014年第4期692-696,共5页 神经科学通报(英文版)
基金 supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA
关键词 carboxypeptidase E NF-α1 NEUROPROTECTION STRESS neurodegenerative disease carboxypeptidase E NF-α1 neuroprotection stress neurodegenerative disease
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