健胃消食口服液治疗儿童功能性消化不良临床症状的改善及胃电图的影响

Influence of Jianwei Xiaoshi Koufuye treatment on clinical symptoms and electrogastrogram in children with functional dyspepsia

目的:探讨健胃消食口服液治疗儿童功能性消化不良(functional dyspepsia,FD)的临床效果.方法:对1-14岁的80例门诊就诊的FD儿童进行随机分组,治疗组作治疗前后自身配对对照研究.治疗组予健胃消食口服液治疗,1-2岁1次5 mL(半支),2次/d;3-12岁1次10 mL(1支),2次/d.疗程15 d后复诊.对照组只给予赖氨酸肌醇维生素B12溶液口服,<2岁2.5 mL/次,3次/d,2-7岁5 mL/次,3次/d.应用消化动力检测系统监测患儿胃电图相关指标变化比较分析两组患者的临床疗效.结果:治疗组腹痛、腹胀、食少早饱、恶心呕吐临床症状改善比例明显优于对照组(95%vs 70%、92.5%vs 75%、97.5%vs 60%、90%vs 72.5%),差异有统计学意义(P<0.05);治疗组总有效率明显高于对照组(92.5%vs 77.5%,P<0.05);治疗组患儿餐前胃电节律在治疗后与治疗前有明显差异(N,73.1±3.0 vs 38.5±4.6)、(B,25.4±3.3 vs 52.4±6.2),治疗后胃动过缓明显降低,正常节律升高,差异有统计学意义(P<0.05);治疗组治疗后餐前的主频明显高于治疗组治疗前(2.8±0.3 vs 1.6±0.4),差异有统计学意义(P<0.05);治疗组在治疗前餐前发生胃动过缓及胃电节律异常的几率分别为22.5%、32.5%,餐后发生胃动过缓及胃电节律异常的几率分别为17.5%、27.5%,均高于治疗组治疗后的发生率(P<0.05).两组均未观察到明显的药物不良反应.结论:健胃消食口服液对儿童功能性消化不良有较好的临床治疗效果且不良反应较少.

AIM： To investigate the influence of treatment with Jianwei Xiaoshi Koufuye on gastric motility and electrogastrogram（EGG） in children with functional dyspepsia.METHODS： Eighty out-patient children with functional dyspepsia treated at our hospital from September 2012 to December 2013 were randomly divided into two groups： a control group and a treatment group. Children in the treatment group at the age between 1 and 2 years received 5 mL of Jianwei Xiaoshi Koufuye every time, twice a day, while those at the age between 3-12 years received 10 mL of Jianwei Xiaoshi Koufuye every time, twice a day. Children in the control group under age of 2 years received vitamin B12 2.5 mL every time, three times a day, while those at the age between 2 to 7 years received vitamin B12 5 mL every time, three times a day. After 15 days of treatment, the efficacy was compared between the two groups. RESULTS： Improvement of symptoms was more significant in the treatment group than in the control group. The total response rate was significantly higher in the treatment group than in the control group（92.5% vs 77.5%, P〈0.05）. The rate of preprandial normal EGG after treatment was significantly higher than that before treatment in the treatment group（73.1 ± 3.0 vs 38.5 ± 4.6, P〈0.05）, while the rate of bradygastria after treatment were significantly lower than that before treatment（25.4 ± 3.3 vs 52.4 ± 6.2, P〈0.05）. The basic frequency after treatment was significantly higher than that before treatment in the treatment group（2.8 ± 0.3 vs 1.6 ± 0.4, P〈0.05）, while the rates of pre- and post-prandial bradygastria and abnormal EGG rhythm before treatment were significantly higher than those after treatment（P〈0.05）. No side effects were observed in both groups.CONCLUSION： Jianwei Xiaoshi Koufuye in children with functional dyspepsia has good curative effect and few adverse reactions.