有氧运动配合雷洛昔芬对骨生物力学性能影响的研究

Aerobic Exercise Combined with Effects of Raloxifene on Bone Biomechanical Properties

目的:通过对去势大鼠骨生物力学指标的检测,探讨有氧运动与雷洛昔芬联合作用对去势大鼠骨生物力学性能的影响。方法:将50只雌性SD大鼠随机分为5组:假手术组、模型组、有氧运动组、雷洛昔芬组、有氧运动+雷洛昔芬组。假手术组不去卵巢,其余各组去卵巢造模;有氧运动组、雷洛昔芬组、有氧运动+雷洛昔芬组分别在去卵巢的基础上进行有氧运动训练和(或)灌胃选择性雌激素受体调节剂雷洛昔芬。8周后比较各组大鼠股骨结构力学和材料力学指标的变化。结果:(1)与模型组相比,有氧运动组、雷洛昔芬组、有氧运动+雷洛昔芬组大鼠的各项指标都显著优于模型组(P<0.05),部分指标出现显著性差异(P<0.01)。(2)模型组各项指标都与假手术组有显著性差别(P<0.05)。结论:有氧运动配合雷洛昔芬治疗联合应用预防废用性骨质疏松比单独应用能获得更好的效果;并且更加安全易行。

Objective： ovariectomized rats bone biomechanical indicators detect, investigate the combined effects of aerobic exercise and raloxifene on ovariectomized rats bone biomechanical properties. Methods： 50 female SD rats were randomly divided into five groups： sham operation group, model group, aerobic exercise group, the raloxifene group, aerobic exercise ＋ raloxifene group. Sham group only surgery but not ovariectomy, the rest of the group of ovariectomized modeling; aerobic exercise group, the raloxifene group aerobic exercise ＋ raloxifene groups, respectively, based on ovariectomized aerobic exercise training and （or） orally selective estrogen receptor modulator raloxifene. After eight weeks, comparing changes in the rat femur structural mechanics and material mechanics index. Results： （1） Compared with model group, the aerobic exercise group, raloxifene group, the indicators of aerobic exercise ＋ raloxifene rats significantly better than the model group （P〈0.05）, part of indicators appear very significant difference （P〈0.01）.（2） Indicators of the model group and the sham group showed significant difference （P〈0.05）. Conclusion： Aerobic exercise and RLX in treatment of combined use of prevent disuse osteoporosis has better control effect than single applications; Applying this method to prevention and treatment of osteoporosis middle-aged and old women will be safer, convenient.