尿液CYFRA21-1诊断膀胱癌的Meta分析

Meta analysis of urine CYFRA21-1 in diagnosis of bladder carcinoma

目的：对尿液细胞角蛋白19-片段（CYFRA21-1）诊断膀胱癌的准确性进行系统评价。方法检索1990～2013年间国外公开发表的关于CYFRA21-1诊断膀胱癌的文献，对纳入的文献进行质量评价并进行Meta分析。结果共有11篇文献纳入，纳入研究对象3395例。CYFRA21-1并发的敏感度和特异性为71％和75％，拟合CYFRA21-1的SROC曲线下面积AUC为0．9082。结论尿液CYFRA21-1在诊断膀胱癌时有较好的准确性，可以作为膀胱癌诊断的辅助检查。

Objective To evaluate the accuracy of diagnostic test of urine CYFRA 21-1 for bladder carcinoma . Methods All the published clinical studies that evaluated the diagnostic value of CYFRA 21-1 in bladder carcinoma from 1990 to 2013 were analyzed .The quality of the tudies which were included evaluated according to the requirements of Meta-analysis .All the eligible studies will be analyzed by the Meta-analysis .Results Eleven studies were collected and the sample size was 3395 cases .The pooled sensitivity [95% confidence interval （CI）] was 71% （68%to 73% ）and the pooled specificity [95% confidence interval （CI）] of CYFRA21-1 was 75% （73% to 77% ） .And the area under SROC （AUC） of CYFRA21-1 was 0 .908 2 .Conclusion CYFRA21-1 is suitiable for the diagnosis of bladder carcinoma .