乙醇所致精神障碍患者血细胞参数的研究

Research of blood cell parameters in alcohol-induced mental disorders

目的探讨乙醇所致精神障碍患者血细胞参数的变化,从而为乙醇所致精神障碍患者提供一个实验室参考指标。方法选取广州医科大学附属脑科医院2011年2月至2013年8月收治的113例乙醇所致精神障碍患者(患者组)和120例健康体检者(健康对照组),分别检测两组血细胞参数指标,并对两组数据进行分析和比较。结果乙醇所致精神障碍患者血液红细胞(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、血小板(PLT)、平均血小板容积(MPV)、淋巴细胞计数(LYMPH#)明显降低,平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、红细胞分布宽度、中性粒细胞计数和单核细胞计数明显升高,平均血红蛋白浓度和白细胞无明显变化。结论红细胞的MCV、MCH的检测可以作为乙醇所致精神障碍的一个监测指标。

Objective To explore changes of blood cell parameters in alcohol-induced mental disorders ,so as to provide a monitoring parameter for alcohol-induced mental disorders .Methods 120 cases of healthy people and 113 cases of alcohol-induced mental disorders were selected in our hospital from February 2011 to August 2013 ,the 113 cases of alcohol-induced mental disorders were taken to be research group ,and the 120 cases of healthy people were taken to be control group .Then blood cell parameters were measured by Mindray BC-6800 Automated Hematology Analyzer ,and then the results of the both groups were analyzed and compared .Results There were significant difference of RBC ,Hb ,HCT ,PLT ,MPV ,LYMPH # ,MCV、MCH、RDW、NEUT # and MONO # between alcohol-induced mental disorders and healthy people ,and there were no statistically significant difference in MCHC and WBC between two groups .Conclusion MCV and MCHC level can be used as a monitoring parameter for alcohol-induced mental disorders .