纳洛酮对新生儿缺氧缺血性脑病的疗效 预后及相关因素水平的影响

Study of naloxone on neonatal hypoxic-ischemic encephalopathy efficacy,prognosis and influence on BDNF,S100B and NSE levels

目的探讨纳洛酮对新生儿缺氧缺血性脑病(HIE)的疗效、预后及其神经营养因子(BDNF)、S100B和神经特异性烯醇化酶(NSE)水平的影响。方法将该院诊治的80例HIE患儿随机分为纳洛酮组和对照组,每组各40例。观察纳洛酮对两组患儿的临床疗效、预后,并检测BDNF、S100B和NSE含量水平的变化。结果治疗后,纳洛酮组的患儿的总体有效率为92.50%(37/40),显著高于对照组的77.50%(31/40)(P<0.05);BDNF、NES和S100B水平均出现不同程度的改变,且纳洛酮组的改善程度显著优于对照组,差异有统计学意义(P<0.05);此外,对照组患儿的智力发育指数(MDI)和运动发育指数(PDI)亦明显低于纳洛酮组,差异有统计学意义(P<0.05);但是两组患儿均未出现严重不良反应。结论纳洛酮治疗HIE能显著提高临床疗效,改善预后和脑损伤指标BDNF、S100B和NSE水平变化。

Objective To investigate naloxone on neonatal hypoxic-ischemic encephalopathy （HIE） efficacy , prognosis and influence on BDNF ,S100B and NSE levels .Methods The 80 cases of HIE in our hospital were randomly divided into naloxone group and control group ,40 cases in each group .Clinical efficacy of naloxone two children ,prognosis ,and to detect changes in BDNF ,S100B and NSE levels were detected .Results After treatment ,the overall effective naloxone group of children was 92 .50% （37/40） ,significantly higher than the 77 .50% （31/40） （P〈0 .05）;BDNF ,NSE and S100B levels were varying degrees of change ,and the degree of improvement naloxone group was significantly better than the control group （P〈 0 .05） .Children in the control group were significantly lower than MDI and PDI naloxone group （P〈0 .05） .But the two groups of children with no serious adverse reactions .Conclusion Naloxone treatment can significantly improve the clinical efficacy of HIE and improve prognosis and brain damage indicators BDNF ,S100B and NSE levels .