糖尿病足患者血流变与黏附因子变化及意义

Significance of changes in blood flow and adhesion molecules in patients with diabetic foot

目的探讨糖尿病足患者血流变与黏附因子变化并进行相关性分析。方法选择糖尿病足患者104例,根据Wagner分级分为1级、2级、3级,每组分别有36、36、32例。入选后分别行血流变及细胞黏附因子1(ICAM-1)、血管内皮细胞黏附因子1(VCAM-1)检测。结果 2级患者低切黏度、血浆比黏度较1级患者有显著性升高,差异有统计学意义(P<0.05),3级患者低切黏度、血小板聚集指数、血浆比黏度较1级、2级患者有显著性升高,差异有统计学意义(P<0.05),高切黏度较1级患者相比差异有统计学意义(P<0.05)。2级患者ICAM-1、VCAM-1较1级患者有显著性升高,差异有统计学意义(P<0.05),3级患者ICAM-1、VCAM-1较1级、2级患者有显著性升高,差异有统计学意义(P<0.05)。ICAM-1与低切黏度、血浆比黏度显著正相关性,差异有统计学意义(P<0.05),VCAM-1与低切黏度、血小板聚集指数、血浆比黏度比较差异有统计学意义(P<0.05)。结论糖尿病足患者存在显著的血流变与黏附因子异常,两者密切相关,共同参与糖尿病足的发生及发展。

Objective To investigate the significance of changes in blood flow and adhesion molecules in patients with diabetic foot .Methods 104 patients with diabetic foot according to Wagner classification were divided into grade one ,two ,three ,which had respectively 36 ,36 ,32 cases .Blood flow changes and ICAM-1 ,VCAM-1 were detected .Results Low shear viscosity ,plasma were significantly increased in grade two patients compared to grade 1 patient （P〈0 .05） ,low shear viscosity ,platelet aggregation index ,plasma viscosity of grade 3 compared with grade one ,two patients significant increased （P〈0 .05） ,compared with high shear viscosity of grade 1 patients showed significant difference （P〈0 .05） .ICAM-1 ,VCAM-1 of grade 2 patients compared with grade 1patients significantly increased （P〈0 .05） ,ICAM-1 ,VCAM-1 of grade 3 compared with grade 1 ,2 patients were significantly higher （P〈0 .05） .ICAM-1 and low shear viscosity ,plasma viscosity showed significant positive correlation （P〈0 .05） ,VCAM-1 and low shear viscosity ,platelet aggregation index ,plasma viscosity was significantly associated （P〈0 .05） .Conclusion Patients with diabetic foot showed significant changes in blood flow abnormalities and adhesion molecules , which are closely related to participate in the occurrence and development of diabetic foot .