健脾生血颗粒联合富马酸亚铁治疗小儿缺铁性贫血90例疗效观察

Clinical observation of 90 cases of pediatric iron deficiency anemia treated with Jianpi Shengxue Granule and ferrous fumarate

目的探讨富马酸亚铁联合健脾生血颗粒治疗小儿缺铁性贫血的临床效果及安全性。方法选取缺铁性贫血患儿180例,采用随机数字表法分为对照组和治疗组,每组各90例。对照组患儿采用硫酸亚铁口服,治疗组患儿则采用健脾生血颗粒联合富马酸亚铁治疗。结果治疗组显效71例,有效18例,无效1例,总有效率为98.89%;对照组显效43例,有效32例,无效15例,总有效率为83.33%。2组总有效率比较差异有统计意义(P<0.05)。2组治疗前血红蛋白(Hb)、平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)、血清铁和铁蛋白比较,差异均无统计意义(P>0.05);2组治疗后Hb,MCV,MCH、血清铁和铁蛋白均较治疗前显著升高(P<0.05),且治疗组改善作用优于对照组(P<0.05)。结论富马酸亚铁联合健脾生血颗粒治疗小儿缺铁性贫血可有效改善缺血症状,降低不良反应发生率,具有临床应用价值。

Objective fumarate on pediatric iron domly divided into control To investigate the clinical efficacy and safety of Jianpi Shengxue Granule with ferrous deficiency anemia. Methods 180 cases of pediatric iron deficiency anemia were rangroup and treatment group, 90 cases in each group. The control group was treated with oral ferrous sulfate, the treatment group with the Jianpi Shengxue Granule combined with ferrous fumarate. Results In the treatment group, 71 cases were markedly effective, 18 cases effective, 1 case invalid, and the total effective rate was 98.89% ; in the control group, 43 cases were markedly effective, 32 cases effective, 15 cases invalid, and the total efficiency was 83.33%. There was statistical significant difference between the two groups （P〈 0.05 ） ; before treatment, there was no statistical significance between the 2 groups in Hb, MCV, MCH, serum iron and ferritin （P〉0.05） ; after treatment, Hb, MCV, MCH, serum iron and ferritin were significantly higher than that before treatment （P〈0.05 ）, and the effect of treatment group was better than of the control group （ P〈 0.05 ）. Conclusion Jianpi Shengxue Granule plus errous fumarate can effectively improve ischemic symptoms, reduce the incidence of adverse reaction in treating iron deficiency anemia, worthy of clinical application.