铑催化芳酮脱羰基合成联芳基化合物

Synthesis of Biaryls via Decarbonylation from Aryl Ketone Catalyzed by Rhodium(Ⅰ)

以含氮杂环为导向基、过渡金属铑络合物[Rh(cod)Cl]2为催化剂,通过碳碳键活化将芳酮化合物脱羰基合成联芳基化合物。确定最优反应条件为:底物芳酮用量2mmol、铑催化剂[Rh(cod)Cl]2用量2.5%(摩尔分数)、溶剂二甲苯用量5mL、反应温度130℃、反应时间12h,在此条件下,联芳基化合物收率达到90%。

Biaryls was synthesized via decarbonylation from aryl ketone with the C-C bond activation approach by rhodium complex catalyst [Rh（cod）Cl]2 using nitrogen-containing heterocycle as the directing group. The optimal reaction conditions were obtained as follows：the substrate aryl ketone amount was 2 mmol,[Rh （cod）Cl]2 amount was 2.5%（molar fraction）,xylene amount was 5 mL,reaction temperature was 130 ℃,reaction time was 12 h.The yield of biaryls was 90% under the optimal conditions.