急性脑梗死患者血清中SOD、ApoE水平变化的临床意义

Clinical significance of serum SOD and ApoE in cerebral infarction

目的探讨SOD、APOE对预测急性脑梗死的意义。方法对70例急性脑梗死患者(按梗死面积分为大面积梗死22例、中等面积梗死20例、小面积梗死28例)和对照组70例健康体检者进行血清中SOD、ApoE检测结果进行比较。结果急性脑梗死组和对照组血清中SOD、APOE水平差异有统计学意义(P<0.05);大面积脑梗死组血清中SOD、ApoE水平与中等、小面积脑梗死组比较差异有显著统计学意义(P<0.01);中等面积脑梗死组与小面积脑梗死组比较差异有显著统计学意义(P<0.01)。结论SOD、ApoE与急性脑梗死关系密切,可能是急性脑梗死新的观察指标,其浓度水平对急性脑梗死的病情变化及治疗具有重要的价值。

Objective To investigate the predictive significance of SOD and APOE in acute cerebral infarction.Methods 70 cases of enrolled patients were distributed into three subgroups , 22 cases of large cerebral infarction ,20 cases of medium infarction and 28 cases of small infarction , according to the infarct size . The level of SOD and ApoE in serum were compared between patients and the 70 healthy persons respectively . Results SOD and ApoE were increased significantly in cerebral infarction group compared to the control （P〈0. 05 ） ,meanwhile , marked ladder were observed between large infarction subgroup and the medium subgroup as well the medium and the small（P〈0.01）.Conclusions The dates demonstrated that serum SOD and ApoE are correlated to the morbidity of CI and able to be utilized in the evaluation and treatment in cerebral infarction .