摘要
代谢与表观遗传状态改变是肿瘤研究的两个热门领域，近年来有大量研究报道认为代谢状态的失调以及表观遗传状态的改变都与脑胶质瘤的发生与发展有着密切的联系。本文通过胶质瘤细胞中两种重要的代谢酶IDHl以及PKM2的改变为例，阐述其对脑胶质瘤细胞表观遗传状态的影响以及促进脑胶质瘤形成的分子机制。由代谢酶异常而导致表观遗传状态改变是研究脑胶质瘤发病的新机制，未来有望成为脑胶质瘤鉴定和治疗的新靶点。
Alteration of metabolism and epigenetic status are two new focuses in the field of cancer re- search. Recently, more and more reports have demonstrated that the changes of both metabolic enzymes and al- tered epigenetic status have close interrelationship with the pathogenesis and development of gliomas in human. We discuss here the effects of altered metabolic enzymes on epigenetic status in gliomas based on two important altered metabolic enzymes,with the aim to unlock the molecular mechanism on how gliomas occur and progress. This newfound molecular mechanism of how altered metabolic enzymes impact on epigenetic status in gliomas may contribute to the identification of novel therapeutic targets to gliomas in the future.
出处
《实用肿瘤学杂志》
CAS
2014年第4期371-376,共6页
Practical Oncology Journal
