摘要
建立了液相色谱-串联质谱联用测定化妆品中3种芦荟蒽醌类化合物含量的方法。样品经甲醇超声提取,用高效液相色谱分离后,采用电喷雾串联质谱进行定性和定量检测。方法线性范围为10-100 ng/mL,相关系数r大于0.99,最低检出限为3 ng/mL（S/N=3）,高、中、低3个浓度水平的加标回收率在80.4%-95.2%之间,测定值的相对标准偏差（n=6）小于10%。
A sensitive method for determination of three anthraquinone compounds in cosmetics by liquid chromatography tan dem mass spectrometry（LC-MS/MS） was established. The cosmetics sample was ultrasonically extracted by methanol, then was separated and delermined by HPLC-ESI-MS/MS. A linear calibration curve was obtained in the concentration range of 10 to 100 ng/ml.. The linear correlation coefficients of the method were above 0.99. The detection limit of method was 3 ng/mL （S/N = 3）. The recoveries at three levels ranged from 80.4% to 95.2%, with the relative standard deviation （n = 6） of less than 10%
出处
《香料香精化妆品》
CAS
2014年第4期42-44,48,共4页
Flavour Fragrance Cosmetics
基金
质检公益性行业科研专项(编号2012104013-2)
