急性脑梗死中医证型与血清ET-1、vWF、H-FABP、PAO的相关性研究

Study on the Relationship of TCM Syndrome types and Serum ET-1、vWF、H-FABP、PAO in Acute Cerebral Infarction

目的:探讨急性脑梗死中医证型与相关生物学指标的关系。方法:将90例急性脑梗死患者(AIC组)通过中医辨证分为风证、火热证、痰证、血瘀证、气虚证、阴虚阳亢证组各15例,ELISA法测定血清ET-1、vWF、H-FABP、PAO水平,并与15例正常健康者(对照组)进行比较。结果:急性脑梗死组血清ET-1、vWF、H-FABP、PAO含量较对照组明显升高,各中医证型之间差异有统计学意义。结论:血清ET-1、vWF、H-FABP、PAO水平有助于对急性脑梗死的病情程度和证型进行评估或判断,可初步作为急性脑梗死辨证分型的客观化指标。

Objective：To investigate the relationship between TCM Syndrome types and biological indicators in Acute Cerebral Infarction（ACI）. Method： Compared to the 15 healthy controls（ control group） ,90 ACI patients （the ACI group） were divided into 6 TCM Syndrome types （Wind, Fire, Phlegm, Blood stasis, Qi deficiency, Yin deficiency and Tang excess）. Contents of serum ET-1, vWF, H-FABP, PAO were measured by the method of ELISA （enzyme linked immunoabsorbent assay） in the ACI group and control group. Result The contents of serum ET-1 ,vWF,H-FABP,PAO in ACI group were significantly higher than that in the control group;There was statistically significance between each TCM syndrome types. Conclusion：The levels of serum ET-1 ,vWF, H-FABP,PAO might be correlated with the disease severity and syndrome types of AIC, and might be used as an objective syndrome types judgment of AIC.