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阿德福韦酯致低血磷性骨软化症1例病例报道 被引量:1

One case of hypophosphatemic osteomalacia induced by adefovir dipivoxil
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摘要 阿德福韦酯是首个核苷酸类似物抗病毒药,近年发现其低剂量可致低血磷性骨软化症。本文回顾分析我院确诊的1例低剂量阿德福韦酯致低血磷性骨软化症病例,供临床参考。
出处 《世界临床药物》 CAS 2014年第8期493-494,510,共3页 World Clinical Drug
关键词 阿德福韦酯 慢性乙型病毒性肝炎 低磷性骨软化症 范可尼综合征 adefovir dipivoxil chronic hepatitis B hypophosphatemic osteomalacia fanconi syndrome
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  • 1Tamori A, Enomoto M, Kobayashi S, et al. Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. J Viral Hepat, 2010, 17 : 123-129.
  • 2Wong T, Girgis CM, Ngu MC, et al. Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B. J Clin Endocrinol Metab,2010, 95:479-480.
  • 3Girgis CM, Wong T, Ngu MC, et al. Hypophosphataemic osteomalacia in patients on adefovir dipivoxil. J Clin Gastroenterol,2011,45 :468-473.
  • 4Kahn J, Lagakos S, Wulfsohn M, et al. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. JAMA, 1999, 282:2305-2312.
  • 5Izzedine H, Hulot JS, Launay-Vacher V, et al. Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two doubleblind, randomized, placebo-controlled studies. Kidney Int, 2004, 66: 1153-1158.
  • 6Bichet DG . Inherited Disorders of the Renal Tubule// Brenner BM. Brenner & rector's the kidney. 8th ed. Philadelphia: Saunders ,2008 : 1390-1393.
  • 7Ho ES, Lin DC, Mendel DB, et aI. Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol, 2000,11 : 383-393.
  • 8Tanji N, Tanji K, Kambham N, et al. Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum Pathol, 2001, 32 : 734-740.
  • 9Lee HJ, Choi JW, Kim TN, et al. A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus. Korean J Hepatol, 2008, 14:381-386.
  • 10Kwon SY, Ahn SY, Ko SY, et al. A case of osteomalacia related to adefovir in a patient with chronic hepatitis B. Korean J Gastroenterol, 2010, 56 : 117-120.

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