中药加艾灸治疗脾肾阳虚型多囊卵巢综合征不孕128例疗效观察

Observation on Therapeutic Effect of Traditional Chinese Medicine and Moxibustion in Treating 128 Cases of Spleen Kidney Yang Deficiency Type Polycystic Ovary Syndrome Induced Infertility

目的:观察中药联合艾灸疗法对脾肾阳虚型多囊卵巢综合征不孕症患者的临床疗效。方法:将符合标准的250例患者按随机数字表法分为治疗组(128例)和对照组(122例)。对照组采取炔雌醇环丙孕酮片治疗,治疗组采取温肾健脾中药(仙茅根、女贞子、枸杞子、菟丝子、酒黄精、白术、党参、醋香附、淫羊藿、当归、炙甘草、鹿角霜)联合艾灸(关元、气海和足三里)治疗。观察患者治疗后激素水平(T、LH、FSH、和E2)、卵泡数量、基础体温变化情况和受孕情况。结果:治疗组和对照组临床痊愈率分别为42.97%、20.49%,总有效率分别为87.50%、74.59%,基础体温恢复正常率分别为67.97%、40.98%,妊娠率分别为53.13%、26.23%,组间比较,差异均有统计学意义(P<0.01)。2组患者治疗后T、LH和FSH水平均降低,E2水平均升高,组间比较,各项指标差异均有统计学意义(P<0.05)。治疗组患者治疗后左右侧卵巢窦卵泡数目均低于对照组,组间比较,差异均有统计学意义(P<0.05)。结论:温肾健脾中药联合艾灸疗法对脾肾阳虚型多囊卵巢综合征不孕症患者的临床疗效优于炔雌醇环丙孕酮片,可显著改善患者激素水平,恢复基础体温,减少卵泡数量、提高妊娠率。

Objective：To observe the clinical curative effect of traditional Chinese medicine combined with moxibustion therapy on pa-tients with spleen kidney yang deficiency type of polycystic ovary syndrome induced infertility.Methods：Two hundred and fifty patients who met the inclusion criteria were randomly divided into observation group （n=128）and control group （n=122）.The control group a-dopted Ethinylestradiol and Cyproterone Acetate Tablets treatment,and observation group gave patients warming kidney and invigorating spleen herbs （Xianmao,Ligustrum lucidum,medlar,dodder seed,polygonatum rhizome,dangshen,wine,vinegar Rhizoma Cyperi,epime-dium,angelica,licorice root,Cornu Cervi degelatinatum）combined with Moxibustion （Guan Yuan,Qihai and Zusanli）treatment.The hormone levels （T,LH,FSH,and E2 ）,follicle number,basal body temperature changes and pregnancy rates were ovserved.Results：The clinical curative rates of the observation group and the control group were respectively 42.97%and 20.49%,and the total effective rate were 87.50%and 74.59%;the normal rate of recovery of basal body temperature were 67.97%and 40.98%;pregnancy rate were re-spectively 53.13% and 26.23%;all the above indicators between the two groups showed statistically significant differences （P〈0.01）.T,LH and FSH levels decreased after treatment in both groups,and E2 levels were elevated,and the differences were statistically significant between the two groups （P〈0.05 ）.After treatment,left and right side ovarian antral follicle number of patients in the obser-vation group was lower than the control group,group comparison,the differences were statistically significant （P〈0.05 ）.Conclusion：Wenshen Jianpi herbs combined with moxibustion therapy on spleen kidney yang deficiency type of polycystic ovary syndrome shows bet-ter clinical curative effect than ethinylestradiol and cyproterone acetate tablets in patients with infertility,it can significantly improve hor-mone levels,basal body temperature,reduce the number of follicles,and improve the pregnancy rate.