垂体微腺瘤的临床内分泌与病理免疫组化类型相关性研究

Micro pituitary adenomas clinical endocrine correlation with pathologic types of immunohistochemical study

目的对垂体微腺瘤的临床症状体征、内分泌与病理免疫组化类型相关性进行探讨。方法选取2010年1月至2012年12月在本院确诊的垂体微腺瘤患者84例,对其进行内分泌、影像学和病理检查,分析检查结果之间的关系。结果患者出现内分泌症状76例(90.47%),免疫组化阳性组内分泌症状发生率[92.59%(75/81)]较免疫组化阴性组[33.33%(1/3)]高,差异具有显著性(χ2=5.92,P<0.05),表明内分泌症状与免疫组化结果相符。血清泌乳素(PRL)阳性组血清PRL增高及闭经、溢乳或月经失调发生率高于PRL阴性组;生长激素(GH)阳性组血清GH增高及巨人症或肢端肥大发生率高于GH阴性组。结论垂体微腺瘤患者的临床表现、内分泌结果与病理免疫组化类型相关,可用来提高垂体微腺瘤的诊断率与治疗率。

Objective To explore the relationship between the clinical symptoms and endocrine of micro pituitary adenomas and pathological immunohistochemical type. Method We had Choosed 84 patients with micro pituitary adenomas from January 2010 to December 2012 in our hospital, then checked the endocrine, imaging and pathological of them, and analysis the relationship between the test results. Result There were 76 cases（90.47%） had endocrine symptoms in all patients, the immunohistochemical positive endocrine symptoms rate was 92.59%（75/81）, this rate was higher than the immunohistochemical negative group which rate was 33.33%（1/3）, the difference was statistically significant（χ^2=5.92, P〈0.05）, this indicated that the endocrine symptoms consistent with immunohistochemical results. The increased serum PRL and amenorrhea, spilled milk or incidence of menstrual disorder rate of serum prolactin（PRL） positive group were higher than that of PRL negative groups; increased serum GH and gigantism or acromegaly fertilizer rates of growth hormone（GH） positive group were higher than GH negative groups. Conclusion The relationship between the clinical symptoms and endocrine of micro pituitary adenomas and pathological immunohistochemical type is close, this can be used to improve the diagnosis and treatment of pituitary micro adenoma.