摘要
The authors presented an efficient method for the palladium-catalyzed Suzuki cross-coupling reaction with the simultaneous reduction of the aldehyde to a hydroxymethyl group.This method allows halide substituted aryl aldehydes to readily react with arylboronic acids,producing polycyclic aromatic alcohols in moderate to good yields.The reaction was catalyzed by Pd（OAc）2（3％,molar fraction） at 150 ℃ in the presence of 6％（molar fraction）1,4-diazabicyclo[2.2.2]octane（DABCO） and 3 times the molecular weight of K2CO3 in the mixture solvent of N,N-dimethylformamide（DMF）/H2O [V（DMF）∶ V（H2O）=5∶1].
The authors presented an efficient method for the palladium-catalyzed Suzuki cross-coupling reaction with the simultaneous reduction of the aldehyde to a hydroxymethyl group.This method allows halide substituted aryl aldehydes to readily react with arylboronic acids,producing polycyclic aromatic alcohols in moderate to good yields.The reaction was catalyzed by Pd（OAc）2（3％,molar fraction） at 150 ℃ in the presence of 6％（molar fraction）1,4-diazabicyclo[2.2.2]octane（DABCO） and 3 times the molecular weight of K2CO3 in the mixture solvent of N,N-dimethylformamide（DMF）/H2O [V（DMF）∶ V（H2O）=5∶1].
基金
Supported by the Basic Research and Development Program of China（No.2011CB512005） and the National Natural Science Foundation of China（Nos.21362002, 41206077, 81260472）.
