亚胺培南的合成

The synthesis of imipenem

目的合成亚胺培南。方法以碳青霉烯双环母核为起始原料,磷酰化后直接与巯基乙胺盐酸盐反应,所得产物经偶联,氢化得亚胺培南。结果亚胺培南工艺总收率62%,纯度98.6%。结论本工艺操作简单,收率高,纯度好,适合工业化生产。

Objective To synthesize imipenem. Methods Imipenem was prepared from bicyclic keto ester,reacting with cysteamine hydrochloride after phosphrylation,then through the reaction of condensation,and catalytic hydrogenation. Results The process had been successfully implemented to prepare the target compound in 62% overall yield and 98. 6% area purity. Conclusion This process was more suitable for industrial production with simple operation,high purity and high yield.