高频振荡通气治疗重症新生儿呼吸窘迫综合征的效果分析

Effect analysis of high frequency oscillation ventilation in the treatment of severe neonatal respiratory distress syndrome

目的：探讨高频振荡通气（HFOV）治疗重症新生儿呼吸窘迫综合征（RDS）的有效性及安全性。方法选取2008年10月∽2013年12月本院新生儿科收治的152例重症新生儿RDS患者为研究对象,入院后按照抽签随机取样法将其分为对照组（n=76）和观察组（n=76）。两组患儿入院后均给予基础治疗,在此基础上对照组患儿给予常频机械通气模式治疗,观察组患儿给予HFOV治疗。比较两组患儿治疗前后的各血气分析指标（pH、PaO2、PaCO2、OI）。比较两组患儿的住院时间、治愈率及并发症发生率。结果治疗前,两组患儿的各血气指标比较,差异均无统计学意义（P〉0.05）；治疗后,观察组的pH、PaO2水平显著高于对照组（P〈0.05）,PaCO2、OI显著低于对照组（P〈0.05）。对照组患儿的住院时间为（21.5±4.9）d,观察组为（14.7±3.1）d,观察组的住院时间显著短于对照组（t=7.59,P=0.006）。观察组治愈率为94.7%,显著高于对照组的82.9%（χ2=5.37,P=0.018）,并发症发生率为3.9%,显著低于对照组的17.1%（χ2=6.99,P=0.008）。结论 HFOV能明显改善重度新生儿RDS的缺氧状态,改善氧合,缩短住院时间,提高其治愈率,降低并发症发生率,值得临床推广应用。

Objective To explore the effectiveness and safety of high frequency oscillation ventilation （HFOV） in the treatment of severe neonatal respiratory distress syndrome （RDS）. Methods 152 cases of new-born baby with severe neonatal RDS were selected as the research objects from October 2008 to December 2013 hospitalized in Department of neonatologyour of our hospital, according to the random sampling method in the lottery after admission,they were di-vided into the control group （n=76） and the observation group （n=76）.The children of two groups were performed foun-dation treatment after admission,on the basis of this,the control group was given conventional mechanical ventilation mode, Children patients of the observation group were given HFOV treatment.Each blood gas index （pH,PaO2,PaCO2,OI） before and after treatment of children of the two groups was compared.Length of hospital stay,cure rate and incidence rate of complication of children in the two groups were compared. Results Before treatment,each blood gas index chil-dren of the two groups were compared,and there was no statistical difference （P〉0.05）.After treatment,pH,PaO2 level of the observation group were higher than those of the control group （P〈0.05）,PaCO2,OI were significantly lower than those of the control group（P〈0.05）.The hospitalization time of children patients in the control group was （21.5±4.9） days, and it was （14.7±3.1） days in the observation group,the hospital stay in the observation group was significantly lower than that in the control group （t=7.59,P=006）.Cure rate of the observation group was significantly higher than that of the control group （94.7% vs 82.9%,χ2=5.37,P=0.018）,incidence rate of complication in the observation group was signifi-cantly lower than that of control group （3.9% vs 17.1%,χ2=6.99,P=0.008）. Conclusion HFOV can obviously improve anaerobic condition of severe neonatal RDS,improve oxygenation,shorten hospitalization time,improve the cure rate and reduce the incidence rate of complication.It is worthy of popularization and application in clinic.