绣球化学成分研究

Studies on chemical constituents of Hydrangea macrophylla

目的：对绣球茎枝水提取物进行化学成分研究。方法采用大孔树脂、硅胶柱色谱、高效制备液相等方法,对绣球茎枝水提取物进行化学成分分离,并通过1H,13C-NMR,MS等波谱方法鉴定化合物的结构。结果分离得到9个化合物,分别鉴定为马钱苷元（1）,马钱子苷（2）,马钱苷酸（3）,幼枝含断氧化马钱子苷（4）,四乙酰开联番木鳖苷（5）,獐牙菜苷（6）,阿魏酸（7）,对羟基桂皮酸（8）,松柏苷（9）。结论化合物均1∽6为首次从该植物中分离得到。

Objective To study the chemical constituents of Hydrangea macrophylla. Methods Nine compounds were separated and purified by column chromatography over macroporous resin,silica gel and preparative HPLC.Their chemi-cal structures were elucidated by MS,1H and 13C-NMR data. Results Nine compounds were isolated from the leaves of Hydrangea macrophylla and identified as loganetin （1）,loganin （2）,loganic acid （3）,secoxyloganin （4）,secologanoside（5）, sweroside（6）,ferulic acid（7）,p-hydroxy cinnamic acid（8） and coniferin（9）. Conclusion Compounds 1-6 are isolated from Hydrangea macrophylla for the first time.