曲美他嗪联合辛伐他汀治疗不稳定型心绞痛的临床效果分析

Clinical efficacy of trimetazidine combined with simvastatin in treatment of unstable angina

目的探讨曲美他嗪联合辛伐他汀治疗不稳定型心绞痛的临床效果。方法选择不稳定型心绞痛患者60例为研究对象,将其随机分为联合组和对照组,对照组采用常规治疗,联合组在常规治疗基础上加用曲美他嗪联合辛伐他汀治疗。比较两组的临床疗效。结果联合组总有效率为93.3%,对照组为70.0%,两组比较差异有统计学意义(P<0.05)。两组治疗后平均每天发作次数显著下降,平均每次发作时间显著缩短,且联合组改善更显著(P<0.01)。治疗后联合组血脂、CRP及白细胞计数指标较对照组显著改善(P<0.01)。结论曲美他嗪联合辛伐他汀治疗不稳定型心绞痛能显著改善疗效,值得临床推广应用。

Objective To discuss the clinical efficacy of trimetazidine combined with simvastatin in treatment of unsta-ble angina. Methods 60 cases of patients with unstable angina for the study were randomly divided into combination group and the control group,control group were received conventional treatment and combination group were treated with trimetazidine combined with simvastatin on the basis of conventional therapy.Clinical efficacy was compared. Results The overall result of the combination group was 93.3% and 70.0% in the control group,the difference between two groups was significant （P〈0.05）.The number of times per day of two groups before and after treatment significantly decreased,and average onset time was significantly shorter,but the more significant improvement in the combination group （P〈0.01）.After treatment,the lipids,CRP and WBC of combination group improved more than that of the control group （P〈0.01）. Conclusion Trimetazidine combined with simvastatin for unstable angina can significantly improve the efficacy,is worthy of promotion.