VEGF与卵巢癌的研究进展

Research progress on VEGF and ovarian cancer

血管内皮生长因子(VEGF)及其受体在卵巢癌高表达,与卵巢癌的发生、发展、转移和预后等密切相关。VEGF受体不仅有酪氨酸激酶活性,而且可刺激血管内皮的分裂、增殖,促进肿瘤血管的生成,提高微血管的通透性,加快肿瘤细胞与血管内营养物质的交换,促进肿瘤的发生、发展。

Vascular endothelial growth factor （VEGF）is a highly specific mitogen for vascular endothelial cells.It po-tentiates angiogenesis and promotes the vascular permeability.Strong expression of VEGF and its receptor has been found in various solid tumor types,including ovarian carcinoma.VEGF receptor not only has tyrosine kinase activity,but also can stimulate endothelial division,proliferation,promote angiogenesis,improve microvascular permeability,accelerate the exchange of nutrients tumor cells and blood vessels,promoting the development of tumor.