凋亡对神经元发育的作用

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摘要神经生长因子被认为是调节神经元发育的主要因素。近年研究发现发育过程中皮质中间神经元的存活或死亡由独立于外部影响的因素决定(如凋亡),挑战现有的神经营养理论。神经生长因子也可以调节和诱导神经元的凋亡。

作者王誉雅金晔麒

机构地区四川大学华西基础医学与法医学院

出处《科技视界》 2014年第25期146-146,共1页 Science & Technology Vision

关键词凋亡神经元发育神经生长因子神经营养理论

参考文献9

1Aloe L, Bracci-Laudiero L, Bonini S, Manni L:The expanding role of nerve growth factor:, from neurotrophic activity to immunologic diseases[J].Allergy,1997,52: 883-894.
2Southwell DG, Paredes MF, Galvao RP, et al. Intrinsically determined cell death of developing cortical interneurons[J]. Nature, 2012,491(7422): 109-113.
3Frank MLStephen MM:Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disee[J].Nature Reviews Drug Discovery, 2013,12:507-525.
4Buss RR, Sun W, Oppcnheim RW. Adaptive roles of programmed cell death during nervous system development[J]. Annu Rev Neurosci, 2006,29:1-35.
5Aloe L, Rocco ML, Bianchi P, et al. Nerve growth factor: from the early discoveries to the potential clinical use[J]. J Transl Med., 2012,10:239.
6Fahnestock M, Yu G, Coughlin MD:ProNGF: a neurutrophic or an apoptotic molecule?[J]Prog Brain Res., 2004,146:101-110.
7Eibl JK, Strasser BC, Ross GM. Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor [J]. Neurochem Int, 2012,61(8): 1266-1275.
8MeAllister AK:Neurotrophins and neuronal differentiation in the central nervous system[J].Cell Mol Life Sci., 2001,58:1054-1060.
9Nikoletopoulou V, Liekert H, Frade JM, et al. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not[J]. Nature, 2010, 467(7311):59- 63.

科技视界

2014年第25期

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