同步放化疗与单纯放疗治疗局部晚期宫颈癌的Meta分析

Meta analysis of chemotherapy combination with radiotherapy versus radiotherapy alone in the treatment of locally advanced cervical carcinoma

目的：系统评价同步放化疗和单纯放疗治疗宫颈癌的有效性。方法计算机检索Cochrane Library、PubMed、Embase、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库。全面查找有关同步放化疗和单纯放疗治疗宫颈癌的随机对照试验，两名评价者单独评价纳入研究的方法学质量并提取资料，用RevMan 5.1软件进行Meta分析。结果共纳入文献10篇， Meta分析结果显示：同步放化疗组和单纯放疗组比较，两组在总生存率方面差异有统计学意义（RR＝1.17，95%CI：1.10～1.24），两组在总有效率方面差异有统计学意义（RR＝1.24，95%CI：1.16～1.33）。结论当前临床证据表明与单纯放疗相比，同步放化疗可提高局部晚期宫颈癌患者的有效率和生存率。

Objective To systematically assess the efficacy of chemotherapy combination with radiotherapy versus radiotherapy alone in the treatment of locally advanced cervical carcinoma. Methods We searched Embase, Pubmed, the Cochrane Library, VIP, CNKI, Chinese biomedicine literature database for randomized controlled trials comparing chemotherapy combination with radiotherapy versus radiotherapy alone in the treatment of locally advanced cervical carcinoma. Two reviewers independently assessed the quality of included studies and extracted data. We analyzed the data using Review Manager （version 5.1）. Results Ten randomized controlled trials totaling were included. Meta analysis showed that there was statistical difference between the radiotherapy alone group and chemotherapy combination with radiotherapy group in overall survival rate （RR=1.17, 95% CI： 1.10-1.24） and overall response rate （RR=1.24, 95%CI：1.16-1.33）. Conclusion Current evidence indicated that compared with radiotherapy alone, chemotherapy combination with radiotherapy could improve overall survival rate （RR=1.17, 95%CI：1.10-1.24） and overall response rate for patient with locally advanced cervical carcinoma.