胰高血糖素样肽-1及其受体激动剂对2型糖尿病患者体重减轻和心血管保护的作用

Effect of glucagon-like peptide-1 and its receptor agonists on weight loss and protection of the cardiovascular system for patients with type 2 diabetes

胰高血糖素样肽-1(GLP-1)属于肠降血糖素激素家族:由远端消化道(回肠和结肠)L细胞(一种内分泌细胞)分泌,以葡萄糖依赖的模式促进胰岛素释放及抑制胰高糖素分泌,从而降低血糖。近年来越来越多的临床证据显示,GLP-1拥有更广泛而重要的胰腺外作用,如通过抑制食欲、延缓胃排空作用使体重减轻,改善内皮细胞功能、心脏功能,抗炎、降脂对心血管起到保护作用。本文就胰高血糖素样肽-1及其受体激动剂对体重减轻和心血管系统影响作一综述。

Glucagon-like peptide-1 （GLP-1） belongs to the incretin hormone family：secreted by the distal gastrointestinal tract （the ileum and colon） L cells （a kind of endocrine cells） and reduces blood glucose through the stimulation of insulin secretion and the inhibition of glucagon release. In recent years, more and more clinical evidences dedicate that GLP-1 possesses more extensive and important functions out of pancreas including slowing gastric emptying, reducing food intake, improving endothelial function, cardiac function, anti-inflammatory response, lowering blood pressure, lipid, reducing weight via inhibiting feeding behavior and delaying gastrointestinal motility, thus it can benefit on cardiovascular function. This paper aimed at reviewing the effects of glucagon-like peptide-1 and its receptor agonists on weight loss and the cardiovascular system.