缺血修饰清蛋白在急性冠状动脉综合征早期诊断中的价值

Earlier diagnostic value of Ischemia modified albumin in acute coronary syndrome patients

目的探讨血清缺血修饰清蛋白(IMA)在急性冠状动脉综合征(ACS)早期诊断中的价值。方法检测117例ACS患者及100例健康体检者血清中IMA及肌酸激酶同工酶(CK-MB)水平,分析IMA检测对于ACS早期诊断中的价值。结果当临界值为73.25U/mL时,血清IMA检测判断ACS的灵敏度、特异性、阳性预测值和阴性预测值分别为89.6%、86.0%、84.93%和94.68%。急性心肌梗死(AMI)组患者的血清中IMA水平明显高于健康对照组(P<0.05)。联合IMA和CK-MB诊断ACS敏感性提升至91.5%,此时特异性为71.5%。结论血清IMA水平可作为ACS早期诊断和危险分层的灵敏指标,联合检测IMA和CK-MB可提高诊断的敏感性。

Objective To explore earlier diagnostic value of ischemia modified albumin（IMA）in acute coronary syndrome（ACS） patients.Methods We detected serum IMA and CK-MB in 117 patients with ACS and 100 healthy controls to analyze the diagnos-tic value of IMA in ACS.Results When the critical value of 73.25 U/mL,serum IMA testing determine the ACS of the sensitivity, specific,positive predictive value and negative predictive value of 89.6%,86.0%,84.93% and 86.0% respectively.IMA levels in serum in patients with AMI group was obviously higher than that of healthy control group（P 〈0.05）.Sensitivity could be improved to 91.5% when detected IMA and CK-MB together.And the specific was 71.5%.Conclusion Serum IMA can be used as sensitive index of early diagnosis and risk stratification of ACS.Detecting IMA and CK-MB can improve the diagnostic sensitivity of ACS.