抗焦虑抑郁治疗对慢性心力衰竭合并焦虑抑郁患者生活质量的影响被引量：7

The Impact of Anti-anxiety and Depression Treatment on Life Quality of the Chronic Heart Failure Patients with Anxiety and Depression

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摘要目的探讨抗焦虑抑郁治疗对合并焦虑抑郁的慢性心力衰竭患者的临床疗效、生活质量的影响。方法将入选的82例伴有焦虑抑郁状态的慢性心力衰竭患者随机分为两组,干预组42例,对照组40例。干预组在常规抗心力衰竭治疗的基础上+舍曲林+心理干预;对照组予常规抗心力衰竭治疗。比较两组治疗前后心功能分级、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分、6 min步行试验、Ang-Ⅱ及NT-proBNP结果。结果干预组患者心功能的改善,HAMA、HAMD评分改善均明显优于对照组,两组治疗后6 min步行试验行走距离、Ang-Ⅱ均较治疗前改善,干预组较对照组疗效更明显(P<0.05);NT-proBNP均较治疗前下降,但两组间差异无统计学意义。结论对有慢性心力衰竭合并焦虑抑郁障碍的患者,在常规纠正心力衰竭治疗基础上联合抗焦虑抑郁治疗,能有效缓解患者的临床症状,改善焦虑抑郁状态、抑制交感过度激活,改善患者的生活质量。 Objective To investigate the effect of anti-anxiety and depression treatment on life quality and emotional disorder in the chronic heart failure patients with anxiety and depression. Method 82 patients with chronic heart failure accompanied by anxiety and depression were randomly divided into intervention group（42 cases）and control group（40 cases）.They were given conventional treatment of chronic heart failure, and at the same time the intervention group was given psychological treatment and orally administered with senraline hydrochloride. The patients were followed up for 4 weeks. Results There were improvement of NYHA cardiac function grading and 6-minute walking distance in both intervention group and control group, but the efficacy of the former showed significantly greater than the latter＇s（P〈0.05）. Four weeks after treatment the scores of HAMA and HAMD significantly decreased（P〈0.05）, and were less than those of control group（P〈0.05）, those of control group no significant change between before and after treatment. Conclusion Anti-anxiety-depression therapy can improve the clinical symptoms and cardiac function, alleviate the anxiety-depressive mood in chronic heart failure patients with anxiety and depression.

作者张颖莉陆佳

机构地区北京市中西医结合医院心内科北京通州区中医院心内科

出处《中国医药指南》 2014年第24期62-63,共2页 Guide of China Medicine

关键词慢性心力衰竭焦虑抑郁抗焦虑抑郁治疗 Chronic heart failure Anxiety Depression Anti-anxiety-depression therapy

分类号 R541.6 [医药卫生—心血管疾病]

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参考文献7

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二级参考文献6

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