埃索美拉唑三联疗法治疗胃溃疡的效果观察

Effect observation of esomeprazole based triple therapy in the treatment of gastric ulcer

目的：观察和研究埃索美拉唑三联疗法治疗胃溃疡的临床效果。方法选取2012年1月～2013年12月本院收治的78例胃溃疡患者为研究对象，将其随机分为对照组（奥美拉唑三联疗法组）39例和观察组（埃索美拉唑三联疗法组）39例，比较两组治疗后不同时间段的溃疡控制效果、治疗前后的血清胃蛋白酶原及白介素-6。结果观察组治疗后2、4周的溃疡控制总有效率均高于对照组，血清胃蛋白原及白介素-6水平均低于对照组，两组比较差异有统计学意义（P〈0.05）。结论埃索美拉唑三联疗法治疗胃溃疡的临床效果相对更好，更有助于改善患者的功能状态及炎性状态。

Objective To observe and study the clinical effect of esomeprazole based triple therapy in the treatment of gastric ulcer. Methods 78 cases of patients with gastric ulcer in our hospital from January 2012 to December 2013 were selected as study objects and randomly divided into control group（omeprazole based triple therapy group,39 cases） and observation group（esomeprazole based triple therapy group,39 cases）.The control effect of ulcer at different time after the treatment and serum pepsinogen,interleukin-6 before and after the treatment in two groups was compared respectively. Results After treatment of two and fourth weeks,the total effective rate of ulcer control in observation group was higher than that in control group respectively,serum pepsinogen and interleukin-6 level in observation group was lower than that in control group respectively,with statistical difference （P〈0.05）. Conclusion The clinical effect of esomeprazole based triple therapy in the treatment of gastric ulcer is relatively better and it is more helpful for the improvement of function and inflammatory state of patients.