低分子肝素联合血浆置换治疗急性高脂血症胰腺炎的临床价值分析

Clinical value analysis of low molecular heparin combined with plasma exchange in treatment of acute hyperlipidemic pancreatitis

目的观察低分子肝素、胰岛素联合血浆置换治疗急性高脂血症胰腺炎的临床价值。方法选择本院收治的84例急性高脂血症胰腺炎患者,按照随机分组原则分为对照组与观察组,每组42例。对照组应用低分子肝素、胰岛素联合治疗,观察组在对照组治疗的基础上应用血浆置换治疗,比较两组的治疗效果,观察治疗前后肿瘤坏死因子-α(TNF-α)、血清淀粉酶及三酰甘油(TG)水平的变化。结果观察组总有效率显著高于对照组,差异有统计意义(P<0.05)。两组治疗前TNF-α、血清淀粉酶及TG水平差异无统计学意义(P>0.05),治疗后两组TNF-α、血清淀粉酶及TG水平均显著改善(P<0.05),且观察组改善情况显著优于对照组(P<0.05)。结论低分子肝素、胰岛素联合血浆置换治疗急性高脂血症胰腺炎效果明显,值得临床推广应用。

Objective To observe the clinical value of low molecular heparin,insulin and plasma exchange in the treat-ment of acute hyperlipidemic pancreatitis （HLP）. Methods Eighty-four patients with acute HLP admitted into our hos-pital were evenly divided into control group and observation group in random.Low molecular heparin and insulin was given to the control group,while plasma exchange was added to the observation group on the basis of the control group. The therapeutic effect and levels of tumor necrosis factor-α （TNF-α）,serum amylase,triglyceride （TG） before and after treatment were compared. Results The total effective rate in the observation group was higher than that in the control group,the difference was significant （P〉0.05）.Before treatment,there was no significant difference about the level of TNF-α,serum amylase and TG in both groups （P〉0.05）.After treatment,these three indexes in the two groups were im-proved （P〈0.05）,and the improvements in the observation group were superior to those in the control group （P〈0.05）. Conclusion In the treatment of acute HLP,low molecular heparin,insulin and plasma exchange can obtain a remarkable effect,which is worthy of expansion and application in clinic.