妊娠期淋病对妊娠结局的影响及治疗分析

Influence of Gonorrhea during Gestational Period on Pregnancy Outcome and Treatment Analysis

目的探讨妊娠期淋病对妊娠结局的影响及有效的治疗方法。方法选择保定市妇幼保健院2010年6月—2013年12月收治的妊娠期淋病终止妊娠63例(终止妊娠组)、妊娠期淋病继续妊娠65例(继续妊娠组)及非妊娠期淋病50例(对照组),均采用抗生素正规治疗,比较3组治疗后7 d治愈率、治疗后3个月复发率及治疗后6个月总治愈率,并统计继续妊娠组的妊娠结局。结果 3组治疗后7 d治愈率及治疗后6个月总治愈率差异均无统计学意义(P>0.05),治疗后3个月复发率继续妊娠组明显高于其他两组(P<0.05)。继续妊娠组均选择剖宫产分娩,新生儿均足月分娩存活,无胎儿宫内发育迟缓、新生儿淋菌性结膜炎、新生儿淋菌性咽炎及新生儿急性淋病等并发症发生。结论妊娠期淋病患者可继续妊娠,抗生素正规治疗安全、可靠,对妊娠结局的影响有限。

Objective To explore the influence of gonorrhea during gestational period on pregnancy outcome and the effective treatment methods. Methods A total of 63 gonorrhea patients during gestational period who terminated pregnancy （ group A） , 65 gonorrhea patients during gestational period who continued pregnancy （ group B） and 50 gonor-rhea patients who were not pregnant （ control group） during June 2010 and December 2013 were selected. All patients underwent regular antibiotics treatment, and the cure rates 7 d after treatment, the recurrence rates 3 months after treat-ment and the total cure rates 6 months after treatment in the three groups were compared, and then the pregnancy out-comes of group B were statistically analyzed. Results The differences in the cure rates 7 d after treatment and the total cure rates 6 months after treatment in the 3 groups were not statistically significant （P〉0. 05）, while the recurrence rate 3 months after treatment in group B was significantly higher than those in the other two groups （P〈0. 05）. The patients in group B underwent cesarean delivery with full-term newborn and live births, and there were no complications such as intrauterine growth retardation, neonatus gonococcal conjunctivitis, neonatus gonococcal pharyngitis or neonatus acute gonorrhea. Conclusion Gonorrhea patients during gestational period can continue pregnancy, and regular antibiotics treatment during gestational period is safe and reliable with limited influence on pregnancy outcome.