艾迪注射液联合含紫杉醇的化疗方案治疗Ⅲ~Ⅳ期非小细胞肺癌42例

Aidi Injection Combined with Paclitaxel-containing Chemotherapy Protocol in Treatment of 42 Patients with Non-small-cell Lung Carcinoma in Stage Ⅲ- Ⅳ

目的：观察艾迪注射液联合含紫杉醇的化疗方案治疗Ⅲ~Ⅳ期非小细胞肺癌的效果。方法选择解放军222医院肿瘤内科2010年1月-2013年12月收治的Ⅲ~Ⅳ期非小细胞肺癌85例,随机分为实验组42例和对照组43例。实验组采用艾迪注射液＋紫杉醇＋顺铂方案化疗,对照组采用单纯紫杉醇＋顺铂方案化疗。28 d为1个周期,每例至少完成2个周期化疗。第2个周期化疗结束后20 d观察比较两组疗效、症状改善、生活质量、毒性反应发生情况。结果实验组总有效率、临床症状改善率、生活质量提高率均优于对照组（P〈0.05）,Ⅲ~Ⅳ度白细胞减少、血小板减少、恶心呕吐发生率均显著低于对照组（P〈0.01）。结论艾迪注射液联合含紫杉醇的化疗方案治疗非小细胞肺癌,具有化疗增效、改善症状、延长生存期、减轻毒性反应和提高患者生活质量的作用。

Objective To observe the effect of Aidi injection combined with Paclitaxel-containing chemotherapy protocol in treatment of patients with non-small-cell lung carcinoma in stage Ⅲ-Ⅳ. Methods A total of 85 patients with non-small-cell lung carcinoma in stageⅢ-Ⅳduring January 2010 and December 2013 in 222 Hospital of PLA were randomly divided into experimental group （n=42） and control group （n=43）. The experimental group underwent Aidi injection ＋ Paclitaxel （ PT） ＋ Cisplatin chemotherapy protocol, while the control group was treated with the PT ＋ Cis-platin chemotherapy protocol. One cycle was 28 d, and each patient received at least 2 cycles. The therapeutic effect, improvement of clinical symptoms and quality of life and incidence rates of toxic reactions in the two groups were com-pared 20 d after the second cycle was finished. Results Compared with those in control group, the total effective rate, improvement rates of clinical symptoms and quality of life in experimental group were better （P〈0. 05）. The incidence rates of leukopenia, thrombocytopenia, nausea and vomiting in stageⅢ-Ⅳin experimental group were significantly low-er （P〈0. 01）. Conclusion Aidi injection combined with paclitaxel-containing chemotherapy protocol in treatment of patients with non-small-cell lung carcinoma in stageⅢ-Ⅳhas better effects, such as effective chemotherapy, symptom improvement, longer life span prolongation, toxic reaction remission and improvement of quality of life.