慢性阻塞性肺疾病患者血磷浓度分析

The relativity between serum phosphorus concentration of AECOPD and the grade of COPD

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血磷浓度与病情严重程度相关性分析。方法选择2010年1月至2012年1月在我科住院的248例AECOPD患者血磷浓度进行分析,并与动脉血气氧分压(PO2)、二氧化碳分压(PCO2)、用力肺活量(FVC)、第1秒用力呼气量(FEV1)、第1秒用力呼气量占预计值的百分比(FEV1%pre)进行相关性分析。结果 AECOPD22%的患者存在轻度低磷血症,11%患者存在中度低磷血症,3%患者存在重度低磷血症。经治疗病情缓解5%患者存在轻度低磷血症,3.7%患者存在中度低磷血症。血磷浓度与患者年龄无相关性(P>0.05),与肺功能(FVC,FEV1,FEV1%pre)有正相关(P<0.05),与PO2正相关(P<0.05),与PCO2负相关(P<0.05)。结论纠正低磷血症,使患者血磷处于正常范围,是AECOPD治疗中防治呼吸衰竭的一个重要的环节。

Objective To analyse the relativity between serum phosphorus concentration of AECOPD and the grade of COPD.Methods From Jan 2010 to Jan 2012,we test the serum phosphprus concentration of 248 AECOPD patients,and analyse the relativity with PO2, PCO2, FVC,FEV1 ,FEV1%pre.Results there were 22%of AECOPD suffer from low-grade hypophosphatemia , 11%moderate hypophosphatemia ,3% high-grate.After treatment ,5% of COPD had low-grade hypophosphatemia ,3.7% of COPD had moderate hypophosphatemia ,there was unrelativity between serum phosphorus concentration and age of patients （P〉0.05）,posi-tive relativity with respiratory function（FVC,FEV1,FEV1%pre）and PO2（P〈0.05）,negative relativity with PCO2（P〈0.05）. Conclusion It was a important way to treatment and prevent respiratory function failure that improve hypophosphatemia and ensure the serum phosphorus concentration of COPD was normal.