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知柏地黄丸治疗糖调节受损患者的临床研究 被引量:4

Clinical Research of Zhibaidihuang Wan in Treatment of Impaired Glucose Regulation in the Patients
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摘要 目的观察知柏地黄丸对糖调节受损(IGR)患者的临床疗效及对胰岛素抵抗、胰岛β细胞功能的影响。方法 176例IGR患者,随机分为治疗组与对照组,观察结束共脱落及剔除病例19例,纳入统计病例157例,治疗组77例,对照组80例,两组均给予教育及生活方式干预,治疗组在其基础上给予知柏地黄丸口服,治疗12个月后,观察两组体重指数(BMI)、HOMA胰岛素分泌指数(HOMA-β)、早期胰岛素分泌指数(EISI)及HOMA胰岛素抵抗指数(HOMA-IR)的改变。结果两组患者的BMI及HOMA-IR较治疗前均有下降,HOMA-β明显升高,差异有统计学意义(P<0.05,P<0.01);与对照组比较,治疗组治疗后HOMA-IR下降,EISI及HOMA-β升高,差异有统计学意义(P<0.05,P<0.01)。结论知柏地黄丸能减轻胰岛素抵抗,改善胰岛β细胞功能,延缓或预防IGR患者向2型糖尿病(T2DM)发展。 Objective To observe the clinical efficacy of Zhibaidihuang Wan on impaired glucose regulation(IGR)and the impacts on insulin resistance(IR)and islet β-cell function.Methods One hun-dred and seventy-six cases of IGR were randomized into a treatment group and a control group.At the end of observation,1 9 cases of them were lost and removed.Totally,1 57 cases were included in final statistical anal-ysis,77 cases in the treatment group and 80 cases in the control group.The education and life style interven-tion was given in the two groups.Additionally,Zhibaidihuang Wan was prescribed for oral administration in the treatment group.In 1 2 months of treatment,BMI,HOMA-β,EISI and HOMA-IR were observed in the two groups.Results BMI and HOMA-IR were reduced as compared with those before treatment in the two groups and HOMA -βwas increased apparently,indicating the significant difference in comparison (P〈0.05,P〈0.01 ).After treatment,HOMA -IR was reduced,and EISI and HOMA -HOMA -βwere in-creased in the treatment group as compared with the control group,indicating the significant difference(P〈0.05,P〈0.01 ).Conclusion Zhibaidihuang Wan alleviates IR,improves islet β-cell function,delays the progression of or prevents from T2DM in IGR patients.
出处 《世界中西医结合杂志》 2014年第8期856-858,共3页 World Journal of Integrated Traditional and Western Medicine
基金 青岛市卫生局2012年度中医科研计划项目(No.2012-zyz002)
关键词 I GR 知柏地黄丸 生活方式干预 胰岛素抵抗 胰岛Β细胞功能 IGR Zhibaidihuang Wan Life Style Intervention Insulin Resistance Islet β-Cell Function
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