基于社区人群的乙型肝炎病毒慢性感染者生存质量多中心调查

Quality of Life among Chronic Hepatitis B Virus Infected People in their Communities

目的开展多中心的基于社区人群的慢性乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染者的生存质量现状调查,分析影响因素。方法应用中文版简明健康调查问卷(Short Form 36 Health Survey Version 2,SF-36v2),对全国31个省(自治区,直辖市)发现的以社区人群为基础的1092名HBV携带者、666名慢性乙肝患者(Chronic Hepatitis B Patient,CHBP)和145名健康对照人群进行生存质量调查。使用卡方检验、Mann-whitney U检验、Kruskal-wallis秩和检验和多元线性回归进行数据分析。结果与对照组相比,HBV携带者在生存质量的8个维度得分、生理维度综合(Physical Component Summary,PCS)总分和心理维度综合(Mental Component Summary,MCS)总分差异无统计学意义(P>0.05);CHBP的生存质量的8个维度得分以及PCS和MCS均降低,差异有统计学意义(P<0.01)。PCS和MCS回归模型显示,家庭年收入、年龄、疾病诊断、地区和性别因素,是影响HBV感染者生存质量的主要因素。结论 CHBP的生存质量较正常人群明显降低。

Objective To assess the quality of life of chronic hepatitis B virus （HBV） infected indi- viduals in their communities and to determine factors that influence quality of life. Methods The short form 36 health survey, version 2, in Chinese （SF-36v2） was used to collect information from 1,092 HBV carriers, 666 chronic hepatitis B patients （CHBP） , and 145 healthy controls, who came from communities in the 31 provinces （Autonomous Regions and Municipalities）. The Chi- square tests, Mann-Whitney U tests, Kruskal-Wallis tests, and multiple-linear regression were used in the data analysis. Results There was no significant, differences in scores in 8 dimensions , phys- ical component summary （PCS） , and mental component summary （MCS） of SF-36 between HBV carriers and controls （P 〉 0.05 ）. However, these scores were all significantly decreased, compa- ring CHBP with controls （P 〈0.01 ）. Annual family income, age, diagnosis group, area and gender were the main factors influencing quality of life of HBV infected people. Conclusion The quality of life for CHBP was significantly lower than for normal controls from communities.